Type: | Domain | Name: | Hepatocyte nuclear factor 1, N-terminal |
Description: | This domain consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerisation sequence [] and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) []. | Short Name: | HNF-1_N |