Protein Domain : IPR014001

Type:  Domain Name:  Helicase superfamily 1/2, ATP-binding domain
Description:  Helicases have been classified in 5 superfamilies (SF1-SF5). All of the proteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B (Mg2+-binding aspartic acid) motifs. For the two largest groups, commonlyreferred to as SF1 and SF2, a total of seven characteristic motifs has been identified []. These two superfamilies encompass a large number of DNA and RNA helicases from archaea, eubacteria, eukaryotes and viruses that seem to be active as monomers or dimers. RNA and DNA helicases are considered to be enzymes that catalyse the separation of double-stranded nucleic acids in an energy-dependent manner [].The various structures of SF1 and SF2 helicases present a common core with two alpha-beta RecA-like domains [, ]. Thestructural homology with the RecA recombination protein covers the five contiguous parallel beta strands and the tandem alpha helices. ATP binds tothe amino proximal alpha-beta domain, where the Walker A (motif I) and WalkerB (motif II) are found. The N-terminal domain also contains motif III (S-A-T) which was proposed to participate in linking ATPase and helicase activities.The carboxy-terminal alpha-beta domain is structurally very similar to the proximal one even though it is bereft of an ATP-binding site, suggesting thatit may have originally arisen through gene duplication of the first one.This entry represents the DNA-binding domain of classical SF1 and SF2 helicases. Short Name:  Helicase_ATP-bd
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3 Child Features

DB identifier Type Name
IPR006935 Domain Helicase/UvrB, N-terminal
IPR011545 Domain DEAD/DEAH box helicase domain
IPR011492 Domain DEAD box, Flavivirus

4 Contains

DB identifier Type Name
IPR014013 Domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR010614 Domain DEAD2
IPR002464 Conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
IPR000629 Conserved_site ATP-dependent RNA helicase DEAD-box, conserved site

2 Cross Referencess

Identifier
PS51192
SM00487

14 Found Ins

DB identifier Type Name
IPR004483 Family Helicase SMUBP-2/Hcs1-like
IPR000330 Domain SNF2-related, N-terminal domain
IPR004589 Family DNA helicase, ATP-dependent, RecQ type
IPR004473 Family Restriction endonuclease, type I, HsdR
IPR004807 Family UvrABC system, subunit B
IPR010225 Family RNA helicase, ATP-dependent DEAH box, HrpB-type
IPR006293 Family DNA helicase, ATP-dependent, RecQ type, bacterial
IPR010222 Family RNA helicase HrpA
IPR006310 Family DnaQ exonuclease/DinG helicase, predicted
IPR006474 Domain Helicase Cas3, CRISPR-associated, core
IPR022307 Family DEAD/DEAH-box helicase, putative, actinobacteria
IPR017548 Family CRISPR-associated DEAD/DEAH-box helicase Csf4
IPR017575 Family CRISPR-associated helicase, CYANO-type
IPR003450 Domain Replication origin-binding protein

0 GO Annotation

0 Ontology Annotations

0 Parent Features

71246 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
10140 D8RF20 PAC:15419664 Selaginella moellendorffii 703  
146823 D8RFZ4 PAC:15404877 Selaginella moellendorffii 428  
410613 D8RFA6 PAC:15407024 Selaginella moellendorffii 1812  
440996 D8RFX1 PAC:15408853 Selaginella moellendorffii 591  
147068 D8RGS1 PAC:15401889 Selaginella moellendorffii 713  
441121 D8RGP3 PAC:15405477 Selaginella moellendorffii 1029  
441099 D8RGG6 PAC:15404839 Selaginella moellendorffii 1198  
441095 D8RGF0 PAC:15404835 Selaginella moellendorffii 1901  
186944 D8TAU2 PAC:15412286 Selaginella moellendorffii 1825  
448879 D8TAY1 PAC:15409151 Selaginella moellendorffii 733  
431801 D8TDU8 PAC:15403532 Selaginella moellendorffii 412  
412612 D8RM23 PAC:15413039 Selaginella moellendorffii 1011  
97186 D8RME5 PAC:15408437 Selaginella moellendorffii 762  
97519 D8RMP3 PAC:15411452 Selaginella moellendorffii 524  
165331 D8QU41 PAC:15412669 Selaginella moellendorffii 786  
165735 D8QW75 PAC:15415760 Selaginella moellendorffii 574  
438217 D8QV44 PAC:15419545 Selaginella moellendorffii 821  
438275 D8QVL3 PAC:15419705 Selaginella moellendorffii 2074  
173103 D8RP98 PAC:15412444 Selaginella moellendorffii 962  
441970 D8RPA1 PAC:15411809 Selaginella moellendorffii 872  
50956 PAC:15409953 Selaginella moellendorffii 755  
98008 D8RP87 PAC:15410517 Selaginella moellendorffii 878  
98495 D8RNP0 PAC:15413842 Selaginella moellendorffii 850  
98462 D8RPL6 PAC:15413761 Selaginella moellendorffii 602  
98552 D8RNW7 PAC:15414518 Selaginella moellendorffii 534  
267628 D8RQ73 PAC:15412754 Selaginella moellendorffii 597  
413731 D8RQ16 PAC:15416714 Selaginella moellendorffii 707  
52088 D8RQ72 PAC:15408926 Selaginella moellendorffii 506  
50459 D8RPT0 PAC:15406067 Selaginella moellendorffii 710  
99840 D8RR30 PAC:15419614 Selaginella moellendorffii 694  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2546125
            11087862
            11839499