Protein Domain : IPR004807

Type:  Family Name:  UvrABC system, subunit B
Description:  The UvrABC repair system catalyses the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage [].This entry represents the UvrB subunit. Short Name:  UvrB
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0 Child Features

2 Contains

DB identifier Type Name
IPR014001 Domain Helicase superfamily 1/2, ATP-binding domain
IPR001650 Domain Helicase, C-terminal

3 Cross Referencess

Identifier
PTHR24029
TIGR00631
MF_00204

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0003677 IPR004807
GO:0005524 IPR004807
GO:0009381 IPR004807
GO:0006281 IPR004807
GO:0006289 IPR004807
GO:0009432 IPR004807

6 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR004807
GO:0005524 IPR004807
GO:0009381 IPR004807
GO:0006281 IPR004807
GO:0006289 IPR004807
GO:0009432 IPR004807

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
53555 C1N749 PAC:27348645 Micromonas pusilla CCMP1545 1800  
63717 C1EFA4 PAC:27402729 Micromonas sp RCC299 1672  
43765 A4SAV4 PAC:27420047 Ostreococcus lucimarinus 690  
Solyc00g041220.1.1 PAC:36127635 Solanum lycopersicum 261  
Pum1565s0001.1.p A0A1X6NL98 PAC:38010306 Porphyra umbilicalis 847  
Solyc00g041220.2.1 PAC:41467686 Solanum lycopersicum 260  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12145219