GO Term : GO:0006289 nucleotide-excision repair GO

Namespace:  biological_process Obsolete:  false
description  A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

10158 Ontology Annotations

Class GO Term Gene Name Db
GOAnnotation GO:0006289 82644  
OntologyAnnotation GO:0006289 82644 GO
GOAnnotation GO:0006289 432615  
OntologyAnnotation GO:0006289 432615 GO
GOAnnotation GO:0006289 422967  
OntologyAnnotation GO:0006289 422967 GO
OntologyAnnotation GO:0006289 121159 GO
GOAnnotation GO:0006289 121159  
GOAnnotation GO:0006289 230853  
OntologyAnnotation GO:0006289 230853 GO
GOAnnotation GO:0006289 73710  
OntologyAnnotation GO:0006289 73710 GO
GOAnnotation GO:0006289 75016  
OntologyAnnotation GO:0006289 75016 GO
GOAnnotation GO:0006289 75917  
OntologyAnnotation GO:0006289 75917 GO
GOAnnotation GO:0006289 77427  
OntologyAnnotation GO:0006289 77427 GO
GOAnnotation GO:0006289 91042  
OntologyAnnotation GO:0006289 91042 GO
GOAnnotation GO:0006289 147068  
OntologyAnnotation GO:0006289 147068 GO
GOAnnotation GO:0006289 449148  
OntologyAnnotation GO:0006289 449148 GO
GOAnnotation GO:0006289 232450  
OntologyAnnotation GO:0006289 232450 GO
GOAnnotation GO:0006289 442877  
OntologyAnnotation GO:0006289 442877 GO
OntologyAnnotation GO:0006289 416209 GO
GOAnnotation GO:0006289 416209  

26 Parents

Identifier Name Description
GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
GO:0006974 cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0044260 cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044710 single-organism metabolic process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0090304 nucleic acid metabolic process Any cellular metabolic process involving nucleic acids.
GO:0034641 cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
GO:0033554 cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:1901360 organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound.
GO:0046483 heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

45 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0006289 GO:0000715
part of GO:0006289 GO:0000716
part of GO:0006289 GO:0000717
part of GO:0006289 GO:0000717
part of GO:0006289 GO:0000718
is_a GO:0006289 GO:0000720
is_a GO:0006289 GO:0006283
is_a GO:0006281 GO:0006289
is_a GO:0090304 GO:0006289
is_a GO:0008152 GO:0006289
is_a GO:1901360 GO:0006289
is_a GO:0008150 GO:0006289
is_a GO:0044238 GO:0006289
is_a GO:0071704 GO:0006289
is_a GO:0033554 GO:0006289
is_a GO:0034641 GO:0006289
is_a GO:0006807 GO:0006289
is_a GO:0043170 GO:0006289
is_a GO:0006725 GO:0006289
is_a GO:0044260 GO:0006289
is_a GO:0046483 GO:0006289
is_a GO:0050896 GO:0006289
is_a GO:0006974 GO:0006289
is_a GO:0006259 GO:0006289
is_a GO:0009987 GO:0006289
is_a GO:0006139 GO:0006289
is_a GO:0051716 GO:0006289
is_a GO:0044763 GO:0006289
is_a GO:0006950 GO:0006289
is_a GO:0044710 GO:0006289

4 Synonyms

Name Type
intrastrand cross-link repair synonym
GO:0045001 alt_id
NER synonym
pyrimidine-dimer repair, DNA damage excision synonym