| Type: | Conserved_site | Name: | ATP-dependent RNA helicase DEAD-box, conserved site |
| Description: | A number of eukaryotic and prokaryotic proteins involved in ATP-dependent, nucleic-acid unwinding have been characterised [, , ] on the basis of their structural similarity. All these proteins share a number of conserved sequence motifs. Some of them are specific to this family while others are shared by other ATP-binding proteins or by proteins belonging to the helicases `superfamily'. One of these motifs, called the 'D-E-A-D-box', represents a special version of the B motif of ATP-binding proteins. Proteins currently known to belong to this family include eukaryotic initiation factor eIF-4A; yeast PRP5, PRP28 and MSS116 splicing proteins, and proteins DHH1, DRS1, MAK5 and ROK1; mouse Pl10, Caenorhabditis eleganshelicase glh-1; Drosophila Rm62 (p62), Me31B and Vasa; and Escherichia coliputative RNA helicases dbpA, deaD, rhlB and rhlE. | Short Name: | RNA-helicase_DEAD-box_CS |
