Protein Domain : IPR012383

Type:  Family Name:  Uroporphyrin-III C-methyltransferase, plant
Description:  Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT), an enzyme of the sirohaem and cobalamin biosynthetic pathway, catalyses C methylation of uroporphyrinogen III () [, ]. It transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. SUMT is the first enzyme committed to the biosynthesis of either sirohaem or cobalamin (vitamin B12) rather than haem, and precorrin-2 is a common intermediate in the biosynthesis of corrinoids such as vitamin B12, sirohaem and coenzyme F430.Members of this family represent a separate, plant-specific group of SUMT (also called UPM). They are characterised by an additional unique N-terminal domain of unknown function, and therefore greater length than the canonical SUMTs. Part of this N-terminal domain resembles a transit peptide for localisation to mitochondria or plastids []. The protein produced by in vitro expression is able to enter isolated intact chloroplasts but not mitochondria [].Canonical stand-alone forms of SUMT are in [, , , , ]. In some bacteria (e.g. Escherichia coli), the SUMT domain is fused to the precorrin-2 oxidase/ferrochelatase domain to form sirohaem synthase (bifunctional CysG protein, ), or to uroporphyrinogen-III synthase to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase (). Short Name:  Uropor_MeTrfase_pln
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0 Child Features

5 Contains

DB identifier Type Name
IPR014777 Domain Tetrapyrrole methylase, subdomain 1
IPR014776 Domain Tetrapyrrole methylase, subdomain 2
IPR000878 Domain Tetrapyrrole methylase
IPR006366 Domain Uroporphyrin-III C-methyltransferase
IPR003043 Conserved_site Uroporphiryn-III C-methyltransferase, conserved site

1 Cross References

Identifier
PIRSF036478

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
AT5G40850.1 Q42606 PAC:37417830 Arabidopsis thaliana 369  
Zm00001d044138_P001 B4F7W3 PAC:40239512 Zea mays 379  
ZmPHJ40.03G304600.1.p A0A3L6FL13 PAC:41363335 Zea mays PHJ40 379  
ZmPHB47.03G346300.1.p B4F7W3 PAC:41443026 Zea mays PHB47 379  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1856165
            9006913
            1906874
            2211520
            2546914
            7959054