Protein Domain : IPR006366

Type:  Domain Name:  Uroporphyrin-III C-methyltransferase
Description:  This domain is found in a family of sequences that represent enzymes, or enzyme domains, with uroporphyrin-III C-methyltransferase activity. This enzyme catalyzes the first step committed to thebiosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). Cobalamin contains cobalt while siroheme contains iron. Siroheme is a cofactorfor nitrite and sulphite reductases and therefore plays a role in cysteine biosynthesis; many members of this family are CysG, siroheme synthase, with an additional N-terminaldomain and with additional oxidation and iron insertion activities. Short Name:  CobA/CysG_C
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0 Child Features

3 Contains

DB identifier Type Name
IPR014777 Domain Tetrapyrrole methylase, subdomain 1
IPR014776 Domain Tetrapyrrole methylase, subdomain 2
IPR003043 Conserved_site Uroporphiryn-III C-methyltransferase, conserved site

1 Cross References

Identifier
TIGR01469

3 Found Ins

DB identifier Type Name
IPR012383 Family Uroporphyrin-III C-methyltransferase, plant
IPR012066 Family Uroporphyrin-III C-methyltransferase, yeast
IPR012409 Family Sirohaem synthase

3 GO Annotations

GO Term Gene Name
GO:0008168 IPR006366
GO:0006779 IPR006366
GO:0055114 IPR006366

3 Ontology Annotations

GO Term Gene Name
GO:0008168 IPR006366
GO:0006779 IPR006366
GO:0055114 IPR006366

1 Parent Features

DB identifier Type Name
IPR000878 Domain Tetrapyrrole methylase

402 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
55881 D8RZ89 PAC:15401514 Selaginella moellendorffii 327  
30152.m002447 B9RHK7 PAC:16820734 Ricinus communis 338  
32684.m000028 B9THR9 PAC:16825519 Ricinus communis 306  
Cucsa.050050.1 A0A0A0KBI8 PAC:16954064 Cucumis sativus 372  
orange1.1g016852m A0A067GXS1 PAC:18101944 Citrus sinensis 381  
AT5G40850.1 Q42606 PAC:19668683 Arabidopsis thaliana 369  
AT5G40850.2 F4KIS7 PAC:19668684 Arabidopsis thaliana 351  
Thhalv10027799m V4LSS1 PAC:20189353 Eutrema salsugineum 371  
Ciclev10031826m V4TKZ0 PAC:20803612 Citrus clementina 380  
Ciclev10031982m V4VI59 PAC:20803613 Citrus clementina 346  
Lus10027819 PAC:23157089 Linum usitatissimum 363  
Lus10037476 PAC:23167059 Linum usitatissimum 338  
Lus10005047 PAC:23148998 Linum usitatissimum 369  
Lus10003913 PAC:23166326 Linum usitatissimum 374  
Potri.001G226900.1 A0A2K2C221 PAC:27044784 Populus trichocarpa 373  
Gorai.011G068800.3 A0A0D2RI12 PAC:26808987 Gossypium raimondii 370  
Gorai.011G068800.6 A0A0D2VJ60 PAC:26808990 Gossypium raimondii 347  
Gorai.011G068800.5 A0A0D2UNN0 PAC:26808989 Gossypium raimondii 366  
Gorai.011G068800.4 A0A0D2UQ12 PAC:26808988 Gossypium raimondii 367  
Gorai.011G068800.2 A0A0D2RI08 PAC:26808986 Gossypium raimondii 376  
Gorai.011G068800.1 A0A0D2VJ65 PAC:26808985 Gossypium raimondii 377  
27543 I0Z5P1 PAC:27390536 Coccomyxa subellipsoidea C-169 282  
7432 I0YZP9 PAC:27391045 Coccomyxa subellipsoidea C-169 230  
22906 C1N6W7 PAC:27348759 Micromonas pusilla CCMP1545 430  
72207 C1DZ77 PAC:27396019 Micromonas sp RCC299 235  
87830 C1EF31 PAC:27402587 Micromonas sp RCC299 435  
4668 A4SAP0 PAC:27420122 Ostreococcus lucimarinus 249  
94394 A4RXX9 PAC:27416713 Ostreococcus lucimarinus 237  
Thecc1EG005935t1 A0A061E3C5 PAC:27436688 Theobroma cacao 374  
Thecc1EG005935t2 A0A061DVE9 PAC:27436687 Theobroma cacao 376  

0 Publications