Protein Domain : IPR014777

Type:  Domain Name:  Tetrapyrrole methylase, subdomain 1
Description:  Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway []. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including cobalamin (vitamin B12), haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [].This entry represents the N-terminal subdomain 1 from several tetrapyrrole methylases, which consist of two non-similar domains. These enzymes catalyse the methylation of their substrates using S-adenosyl-L-methionine as a methyl source. Enzymes in this family include:Uroporphyrinogen III methyltransferase () (SUMT), which catalyses the conversion of uroporphyrinogen III to precorrin-2 at the first branch-point of the tetrapyrrole synthesis pathway, directing the pathway towards cobalamin or sirohaem synthesis [].Precorrin-2 C20-methyltransferase CobI/CbiL (), which introduces a methyl group at C-20 on precorrin-2 to produce precorrin-3A during cobalamin biosynthesis. This reaction is key to the conversion of a porphyrin-type tetrapyrrole ring to a corrin ring []. In some species, this enzyme is part of a bifunctional protein.Precorrin-4 C11-methyltransferase CobM/CbiF (), which introduces a methyl group at C-11 on precorrin-4 to produce precorrin-5 during cobalamin biosynthesis [].Sirohaem synthase CysG (), domains 4 and 5, which synthesizes sirohaem from uroporphyrinogen III, at the first branch-point in the tetrapyrrole biosynthetic pathway, directing the pathway towards sirohaem synthesis [].Diphthine synthase (), which carries out the methylation step during the modification of a specific histidine residue of elongation factor 2 (EF-2) during diphthine synthesis. Short Name:  4pyrrole_Mease_sub1
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0 Child Features

2 Contains

DB identifier Type Name
IPR003043 Conserved_site Uroporphiryn-III C-methyltransferase, conserved site
IPR018063 Conserved_site SAM-dependent methyltransferase RsmI, conserved site

1 Cross References

Identifier
G3DSA:3.40.1010.10

13 Found Ins

DB identifier Type Name
IPR004551 Family Diphthine synthase
IPR000878 Domain Tetrapyrrole methylase
IPR006366 Domain Uroporphyrin-III C-methyltransferase
IPR008189 Family rRNA small subunit methyltransferase I
IPR006362 Domain Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase
IPR012383 Family Uroporphyrin-III C-methyltransferase, plant
IPR006364 Domain Precorrin-2 C(20)-methyltransferase domain
IPR012382 Family Precorrin-2 C(20)-methyltransferase
IPR006363 Domain Precorrin-3B C17-methyltransferase domain
IPR014422 Family Cobalamin (vitamin B12) biosynthesis, bifunctional CbiH/CbiC
IPR012066 Family Uroporphyrin-III C-methyltransferase, yeast
IPR012409 Family Sirohaem synthase
IPR012797 Family Cobalamin (vitamin B12) biosynthesis CobF, precorrin-6A synthase

2 GO Annotations

GO Term Gene Name
GO:0008168 IPR014777
GO:0008152 IPR014777

2 Ontology Annotations

GO Term Gene Name
GO:0008168 IPR014777
GO:0008152 IPR014777

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
444317 D8S8X9 PAC:15415859 Selaginella moellendorffii 605  
30174.m008618 B9RDT7 PAC:16822264 Ricinus communis 547  
27444.m000052 B9TBG4 PAC:16798330 Ricinus communis 172  
AT3G17170.1 Q948R9 PAC:19665046 Arabidopsis thaliana 314  
Lus10022266 PAC:23139487 Linum usitatissimum 2363  
Potri.005G232200.5 PAC:27028103 Populus trichocarpa 205  
Potri.010G110500.1 A0A2K1YS81 PAC:26980276 Populus trichocarpa 594  
Gorai.005G045900.2 A0A0D2PMP8 PAC:26801361 Gossypium raimondii 1210  
Gorai.005G045900.3 A0A0D2R986 PAC:26801362 Gossypium raimondii 1209  
Gorai.005G045900.1 A0A0D2N7W6 PAC:26801360 Gossypium raimondii 1215  
Gorai.010G254200.1 A0A0D2VF97 PAC:26759044 Gossypium raimondii 221  
Gorai.011G068800.8 A0A0D2T3J3 PAC:26808992 Gossypium raimondii 264  
Gorai.011G068800.7 A0A0D2T3J3 PAC:26808991 Gossypium raimondii 264  
Gorai.011G068800.9 A0A0D2T3J7 PAC:26808993 Gossypium raimondii 237  
59554 C1MVY2 PAC:27341008 Micromonas pusilla CCMP1545 262  
55580 C1FEV3 PAC:27399146 Micromonas sp RCC299 352  
Migut.E01372.1.p A0A022QK84 PAC:28920968 Mimulus guttatus 646  
Migut.G00521.1.p PAC:28942905 Mimulus guttatus 88  
Migut.A00529.2.p PAC:28938962 Mimulus guttatus 462  
Glyma.11G109500.1.p K7LP44 PAC:30530422 Glycine max 960  
Brara.D02058.1.p A0A397ZN97 PAC:30620243 Brassica rapa FPsc 215  
Cre03.g156050.t1.2 A0A2K3DW10 PAC:30787296 Chlamydomonas reinhardtii 269  
Cre08.g372950.t1.2 A8JEV9 PAC:30773984 Chlamydomonas reinhardtii 465  
Bradi4g14820.1.p PAC:31144523 Brachypodium distachyon 205  
Medtr1g053970.1 A0A072VJS7 PAC:31093419 Medicago truncatula 181  
Medtr3g105970.1 G7J9U4 PAC:31054352 Medicago truncatula 135  
SapurV1A.1107s0060.5.p PAC:31453807 Salix purpurea 327  
SapurV1A.1107s0060.2.p PAC:31453804 Salix purpurea 395  
SapurV1A.1107s0060.3.p PAC:31453805 Salix purpurea 383  
SapurV1A.0008s0240.2.p PAC:31439976 Salix purpurea 267  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11215515
            17227226
            14595395
            15522295
            16866557
            17229157