Protein Domain : IPR000878

Type:  Domain Name:  Tetrapyrrole methylase
Description:  Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway []. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including cobalamin (vitamin B12), haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [].These enzymes catalyse the methylation of their substrates using S-adenosyl-L-methionine as a methyl source. Enzymes in this family include:Uroporphyrinogen III methyltransferase () (SUMT), which catalyses the conversion of uroporphyrinogen III to precorrin-2 at the first branch-point of the tetrapyrrole synthesis pathway, directing the pathway towards cobalamin or sirohaem synthesis [].Precorrin-2 C20-methyltransferase CobI/CbiL (), which introduces a methyl group at C-20 on precorrin-2 to produce precorrin-3A during cobalamin biosynthesis. This reaction is key to the conversion of a porphyrin-type tetrapyrrole ring to a corrin ring []. In some species, this enzyme is part of a bifunctional protein.Precorrin-4 C11-methyltransferase CobM/CbiF (), which introduces a methyl group at C-11 on precorrin-4 to produce precorrin-5 during cobalamin biosynthesis [].Sirohaem synthase CysG (), domains 4 and 5, which synthesizes sirohaem from uroporphyrinogen III, at the first branch-point in the tetrapyrrole biosynthetic pathway, directing the pathway towards sirohaem synthesis [].Diphthine synthase (), which carries out the methylation step during the modification of a specific histidine residue of elongation factor 2 (EF-2) during diphthine synthesis.This entry represents a tetrapyrrole methylase domain, which consist of two non-similar subdomains []. Short Name:  4pyrrol_Mease
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5 Child Features

DB identifier Type Name
IPR006366 Domain Uroporphyrin-III C-methyltransferase
IPR006362 Domain Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase
IPR012818 Domain Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase
IPR006364 Domain Precorrin-2 C(20)-methyltransferase domain
IPR006363 Domain Precorrin-3B C17-methyltransferase domain

4 Contains

DB identifier Type Name
IPR014777 Domain Tetrapyrrole methylase, subdomain 1
IPR014776 Domain Tetrapyrrole methylase, subdomain 2
IPR003043 Conserved_site Uroporphiryn-III C-methyltransferase, conserved site
IPR018063 Conserved_site SAM-dependent methyltransferase RsmI, conserved site

2 Cross Referencess

Identifier
PF00590
SSF53790

5 Found Ins

DB identifier Type Name
IPR012383 Family Uroporphyrin-III C-methyltransferase, plant
IPR006365 Family Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase
IPR014422 Family Cobalamin (vitamin B12) biosynthesis, bifunctional CbiH/CbiC
IPR012066 Family Uroporphyrin-III C-methyltransferase, yeast
IPR012409 Family Sirohaem synthase

2 GO Annotations

GO Term Gene Name
GO:0008168 IPR000878
GO:0008152 IPR000878

2 Ontology Annotations

GO Term Gene Name
GO:0008168 IPR000878
GO:0008152 IPR000878

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
232025 D8RQI7 PAC:15416526 Selaginella moellendorffii 274  
55881 D8RZ89 PAC:15401514 Selaginella moellendorffii 327  
107529 D8S333 PAC:15421360 Selaginella moellendorffii 306  
evm.model.supercontig_1059.3 PAC:16405146 Carica papaya 274  
evm.model.supercontig_1133.2 PAC:16406091 Carica papaya 340  
evm.model.supercontig_99.13 PAC:16429253 Carica papaya 359  
30152.m002447 B9RHK7 PAC:16820734 Ricinus communis 338  
30170.m014101 B9R806 PAC:16821937 Ricinus communis 363  
30170.m014225 B9R875 PAC:16822058 Ricinus communis 285  
32684.m000028 B9THR9 PAC:16825519 Ricinus communis 306  
Cucsa.050050.1 A0A0A0KBI8 PAC:16954064 Cucumis sativus 372  
Cucsa.159800.1 A0A0A0LLL7 PAC:16965256 Cucumis sativus 286  
Cucsa.231900.1 A0A0A0LRJ7 PAC:16970161 Cucumis sativus 365  
orange1.1g016852m A0A067GXS1 PAC:18101944 Citrus sinensis 381  
orange1.1g030179m A0A067H1Q0 PAC:18092796 Citrus sinensis 181  
orange1.1g031196m A0A067GZ17 PAC:18092797 Citrus sinensis 164  
orange1.1g023387m A0A067GZ13 PAC:18092791 Citrus sinensis 283  
orange1.1g027091m A0A067GYN3 PAC:18092792 Citrus sinensis 228  
orange1.1g027789m A0A067H1P6 PAC:18092795 Citrus sinensis 219  
orange1.1g027088m A0A067GYN3 PAC:18092794 Citrus sinensis 228  
orange1.1g027097m A0A067GYN3 PAC:18092793 Citrus sinensis 228  
orange1.1g023900m A0A067HA91 PAC:18091884 Citrus sinensis 275  
orange1.1g017650m A0A067H1D2 PAC:18091882 Citrus sinensis 368  
orange1.1g016688m A0A067HAM0 PAC:18091881 Citrus sinensis 384  
orange1.1g017645m A0A067H1D2 PAC:18091883 Citrus sinensis 368  
orange1.1g024996m A0A067GYC2 PAC:18091886 Citrus sinensis 259  
orange1.1g024054m A0A067GYP5 PAC:18091885 Citrus sinensis 273  
AT4G31790.2 O81769 PAC:19645850 Arabidopsis thaliana 277  
AT4G31790.1 O81769 PAC:19645849 Arabidopsis thaliana 277  
AT5G40850.1 Q42606 PAC:19668683 Arabidopsis thaliana 369  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11215515
            17227226
            14595395
            15522295
            16866557
            17229157