Protein Domain : IPR001902

Type:  Family Name:  SLC26A/SulP transporter
Description:  The SLC26A/SulP family is a large and ubiquitous family with members derived from archaea, bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterised, and most are inorganic anion uptake transporters or anion:anion exchange transporters. Some transport their substrate(s) with high affinities, while others transport it or them with relatively low affinities [, , ].SLC26A/SulP family proteins consist of N- and C- termini flanking a transmembrane domain thought to span the lipid bilayer 10-14 times. In most casses, the C-terminal cytoplasmic region includes a STAS (sulfate transporter and anti-sigma factor antagonist) domain [].Malfunctions in members of the SLC26A family of anion transporters are involved in three human diseases: diastrophic dysplasia/achondrogenesis type 1B (DTDST), Pendred's syndrome (PDS) and congenital chloride diarrhea (CLD). These proteins contain 12 transmembrane helices followed by a cytoplasmic STAS domain at the C terminus. The importance of the STAS domain in these transporters is illustrated by the fact that a number of mutations in PDS and DTDST map to it [].Proteins in this family include:Neurospora crassasulphate permease II (gene cys-14).Yeast sulphate permeases (genes SUL1 and SUL2).Rat sulphate anion transporter 1 (SAT-1).Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.Human protein DRA (Down-Regulated in Adenoma).Soybean early nodulin 70.Escherichia colihypothetical protein ychM.Caenorhabditis eleganshypothetical protein F41D9.5. Short Name:  SLC26A/SulP_fam
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23 Child Features

DB identifier Type Name
IPR030314 Family Plant high affinity sulfate transporter
IPR030316 Family Sulfate transporter 3.5
IPR030313 Family Sulfate transporter 3.3
IPR030315 Family Plant low affinity sulfate transporter
IPR030311 Family Sulfate transporter 3.1/3.2
IPR030341 Family Anion transporter SULP-7
IPR030340 Family Anion transporter SULP-6
IPR030285 Family Pendrin
IPR030282 Family Prestin
IPR030280 Family Solute carrier family 26 member 2
IPR030331 Family Solute carrier family 26 member 1
IPR030338 Family Anion transporter SULP-4
IPR030339 Family Anion transporter SULP-5
IPR030337 Family Anion transporter SULP-2
IPR030335 Family Anion transporter SULP-1
IPR030329 Family Solute carrier family 26 member 7
IPR030328 Family Anion transporter SULP-3
IPR030323 Family Solute carrier family 26 member 6
IPR030324 Family Solute carrier family 26 member 10
IPR030321 Family Solute carrier family 26 member 3 (DRA)
IPR030317 Family Sulfate transporter 3.4
IPR030306 Family Solute carrier family 26 member 9
IPR030303 Family Solute carrier family 26 member 8 (testis anion transporter 1)

3 Contains

DB identifier Type Name
IPR011547 Domain SLC26A/SulP transporter domain
IPR002645 Domain STAS domain
IPR018045 Conserved_site Sulphate anion transporter, conserved site

2 Cross Referencess

Identifier
PTHR11814
TIGR00815

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008271 IPR001902
GO:0008272 IPR001902
GO:0055085 IPR001902
GO:0016020 IPR001902

4 Ontology Annotations

GO Term Gene Name
GO:0008271 IPR001902
GO:0008272 IPR001902
GO:0055085 IPR001902
GO:0016020 IPR001902

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
113596 D8SC46 PAC:15417147 Selaginella moellendorffii 657  
184750 D8T281 PAC:15404801 Selaginella moellendorffii 677  
169988 D8RBP1 PAC:15406700 Selaginella moellendorffii 646  
90185 D8RD26 PAC:15410407 Selaginella moellendorffii 641  
evm.model.supercontig_1.331 PAC:16404268 Carica papaya 595  
evm.model.supercontig_1395.1 PAC:16408587 Carica papaya 653  
evm.model.supercontig_155.30 PAC:16409751 Carica papaya 670  
evm.model.supercontig_20.224 PAC:16413031 Carica papaya 664  
evm.model.supercontig_23.119 PAC:16414165 Carica papaya 645  
evm.model.supercontig_52.108 PAC:16421963 Carica papaya 656  
evm.model.supercontig_583.2 PAC:16423086 Carica papaya 651  
evm.model.supercontig_65.154 PAC:16424415 Carica papaya 655  
evm.model.supercontig_66.93 PAC:16424662 Carica papaya 659  
evm.model.supercontig_66.96 PAC:16424665 Carica papaya 647  
29703.m001472 B9SFG4 PAC:16806168 Ricinus communis 550  
29816.m000687 B9SJ59 PAC:16809599 Ricinus communis 652  
29844.m003232 B9RTL1 PAC:16810939 Ricinus communis 606  
29848.m004703 B9RPC1 PAC:16811358 Ricinus communis 682  
29872.m000543 B9SQC2 PAC:16811937 Ricinus communis 662  
29877.m000464 B9SSK1 PAC:16811977 Ricinus communis 590  
29908.m005986 B9RJF7 PAC:16812809 Ricinus communis 658  
29908.m005987 B9RJF8 PAC:16812810 Ricinus communis 667  
31378.m000016 B9TKA8 PAC:16824986 Ricinus communis 360  
31385.m000015 B9TD89 PAC:16824994 Ricinus communis 495  
28067.m000105 B9T5Z4 PAC:16799854 Ricinus communis 654  
28155.m000051 B9TAM8 PAC:16800097 Ricinus communis 806  
28435.m000050 B9T9T7 PAC:16800838 Ricinus communis 594  
29479.m000069 B9T7D7 PAC:16802926 Ricinus communis 644  
Cucsa.373230.1 A0A0A0KMN2 PAC:16981835 Cucumis sativus 664  
Cucsa.002530.1 A0A0A0KQT8 PAC:16950913 Cucumis sativus 700  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10662676
            24710176
            23506885
            21070944