Protein Domain : IPR030321

Type:  Family Name:  Solute carrier family 26 member 3 (DRA)
Description:  SLC26A3 or DRA (Down Regulated in Adenoma) is a member of the solute carrier family 26 (SLC26) that plays a major role in mediating Cl- absorption in the intestine. DRA absorbs Cl- and exports HCO3- in the small intestine in a partly carbonic anhydrase II-dependent fashion []. DRA also contributes to sulfate secretion []. Deletion of DRA results in reduced colonic HCO3- secretion, loss of colonic fluid absorption, and a lack of adherent mucus layer []. Mutations in DRA cause congenital chloride diarrhea, characterised by chronic secretory diarrhea containing an excess of chloride [].DRA is also involved in sperm capacitation [, ]. Short Name:  SLC26A3
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11814:SF19

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0015301 IPR030321
GO:0006821 IPR030321
GO:0015701 IPR030321
GO:0005887 IPR030321

4 Ontology Annotations

GO Term Gene Name
GO:0015301 IPR030321
GO:0006821 IPR030321
GO:0015701 IPR030321
GO:0005887 IPR030321

1 Parent Features

DB identifier Type Name
IPR001902 Family SLC26A/SulP transporter

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            24233434
            24373192
            21394828
            23660504
            21976599
            24115633