Protein Domain : IPR030329

Type:  Family Name:  Solute carrier family 26 member 7
Description:  Solute carrier family 26 member 7 (SLC26A7) acts as a sodium-independent DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid)-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport [, , ]. SLC26A7 has been reported to exhibit the Cl-/HCO3- exchange activity [] and the pH-regulated Cl- channel activity with minimal OH-/HCO3- permeability []. Mouse SLC26A7 is localised in the basolateral membrane of gastric parietal cells and of Alpha intercalated cells (A-IC) in outer medullary collecting duct [, ]. Deletion of SLC26A7 in mice causes distal renal tubular acidosis and impaired gastric acid secretion [].Note: DIDS is a stilbene sulfonate that can be used to inhibit anionic transport. Short Name:  SLC26A7
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11814:SF75

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0008509 IPR030329
GO:0001696 IPR030329
GO:0006820 IPR030329
GO:0016021 IPR030329
GO:0016323 IPR030329

5 Ontology Annotations

GO Term Gene Name
GO:0008509 IPR030329
GO:0001696 IPR030329
GO:0006820 IPR030329
GO:0016021 IPR030329
GO:0016323 IPR030329

1 Parent Features

DB identifier Type Name
IPR001902 Family SLC26A/SulP transporter

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16263805
            12965893
            17404755
            15284286
            19723628
            15591059