Protein Domain : IPR008991

Type:  Domain Name:  Translation protein SH3-like domain
Description:  The fundamental activity of the ribosome is two-fold: to decode the message of the mRNA in the small subunit, and to form a peptide bond between peptidyl-tRNA and aminoacyl-tRNA by a peptidyl transferase activity in the large subunit. Several prokaryotic and eukaryotic proteins that are involved in the translation process contain an SH3-like domain. The structure of the translation protein SH3-like domain is a partly opened beta barrel, where the last strand is interrupted by a 3-10 helical turn. The structure of the RNA-binding C-terminal domain of the Bacillus stearothermophilus(Geobacillus stearothermophilus) ribosomal protein L2 has been shown to adopt the SH3-like barrel topology []. The L2 protein is located near the peptidyl transferase centre in the large ribosomal subunit where it may contribute to peptidyl transferase activity, and is involved in the assembly of the 23SrRNA. Likewise, the N-terminal domain of the ubiquitous eukaryotic translation elongation factor 5a (IF5A) protein adopts the SH3-like barrel topology [, ]. IF5A, previously thought to be an initiation factor, is now considered to be involved in translation elongation [] and in cell-cycle regulation. IF5A acts as a cofactor of the Rev protein in HIV-1-infected cells and of the Rex protein in T-cell leukaemia virus 1-infected cells. Short Name:  Translation_prot_SH3-like
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1 Child Features

DB identifier Type Name
IPR022669 Domain Ribosomal protein L2, C-terminal

8 Contains

DB identifier Type Name
IPR014722 Domain Ribosomal protein L2 domain 2
IPR014726 Domain Ribosomal protein L2, domain 3
IPR005824 Domain KOW
IPR022671 Conserved_site Ribosomal protein L2, conserved site
IPR019769 PTM Translation elongation factor, IF5A, hypusine site
IPR005825 Conserved_site Ribosomal protein L24/L26, conserved site
IPR015869 Conserved_site Transcription antitermination protein, NusG, bacteria, conserved site
IPR018259 Conserved_site Ribosomal protein L21e, conserved site

1 Cross References

Identifier
SSF50104

11 Found Ins

DB identifier Type Name
IPR001147 Family Ribosomal protein L21e
IPR002171 Family Ribosomal protein L2
IPR005880 Family Ribosomal protein L2, bacterial/organellar-type
IPR020599 Family Translation elongation factor P/YeiP
IPR011768 Family Translation elongation factor P
IPR001884 Family Translation elongation factor IF5A
IPR003256 Family Ribosomal protein L24
IPR001062 Family Transcription antitermination protein, NusG
IPR011590 Family Transcription elongation factor Spt5, archaeal
IPR010215 Family Transcription antitermination protein RfaH
IPR011897 Family Translation elongation factor P-like, YeiP

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
170971 D8RF89 PAC:15409909 Selaginella moellendorffii 260  
449156 D8TD72 PAC:15406619 Selaginella moellendorffii 931  
137825 D8TEA9 PAC:15422913 Selaginella moellendorffii 287  
96727 D8RM04 PAC:15410061 Selaginella moellendorffii 1003  
227399 D8QWN3 PAC:15404041 Selaginella moellendorffii 147  
7731 D8QXF3 PAC:15404425 Selaginella moellendorffii 97  
80171 D8QXK2 PAC:15403052 Selaginella moellendorffii 186  
443353 D8S0M9 PAC:15413031 Selaginella moellendorffii 566  
17231 D8S6Z5 PAC:15418536 Selaginella moellendorffii 144  
418636 D8S6N5 PAC:15408161 Selaginella moellendorffii 332  
142541 D8R032 PAC:15413434 Selaginella moellendorffii 159  
166700 D8QZM0 PAC:15418564 Selaginella moellendorffii 134  
230291 D8QZ11 PAC:15412464 Selaginella moellendorffii 184  
8180 D8QZ88 PAC:15402927 Selaginella moellendorffii 91  
38168 D8R693 PAC:15412857 Selaginella moellendorffii 153  
403602 D8QRX7 PAC:15408631 Selaginella moellendorffii 133  
270686 D8R9D2 PAC:15421830 Selaginella moellendorffii 173  
17971 D8R928 PAC:15401626 Selaginella moellendorffii 91  
170832 D8RES0 PAC:15409024 Selaginella moellendorffii 160  
evm.TU.contig_34170.1 PAC:16430410 Carica papaya 146  
evm.model.supercontig_1.400 PAC:16404345 Carica papaya 404  
evm.model.supercontig_1.78 PAC:16404424 Carica papaya 159  
evm.model.supercontig_113.11 PAC:16406019 Carica papaya 92  
evm.model.supercontig_113.10 PAC:16406018 Carica papaya 164  
evm.model.supercontig_1296.2 PAC:16407597 Carica papaya 233  
evm.model.supercontig_1348.1 PAC:16408244 Carica papaya 160  
evm.model.supercontig_1469.1 PAC:16409181 Carica papaya 159  
evm.model.supercontig_165.27 PAC:16410367 Carica papaya 134  
evm.model.supercontig_188.8 PAC:16411774 Carica papaya 1039  
evm.model.supercontig_21.98 PAC:16413614 Carica papaya 408  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9753699
            19424157
            10075918
            9724718