Protein Domain : IPR002171

Type:  Family Name:  Ribosomal protein L2
Description:  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].Ribosomal protein L2 is one of the proteins from the large ribosomal subunit. This entry represents the best conserved region located in the C-terminal section of these proteins.In Escherichia coli, L2 is known to bind to the 23S rRNA and to have peptidyltransferase activity. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [], groups:Eubacterial L2.Algal and plant chloroplast L2.Cyanelle L2.Archaebacterial L2.Plant L2.Slime mold L2.Marchantia polymorphamitochondrial L2.Paramecium tetraureliamitochondrial L2.Fission yeast K5, K37 and KD4.Yeast YL6.Vertebrate L8. Short Name:  Ribosomal_L2
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2 Child Features

DB identifier Type Name
IPR005880 Family Ribosomal protein L2, bacterial/organellar-type
IPR023672 Family Ribosomal protein L2, archaeal-type

7 Contains

DB identifier Type Name
IPR012340 Domain Nucleic acid-binding, OB-fold
IPR014722 Domain Ribosomal protein L2 domain 2
IPR008991 Domain Translation protein SH3-like domain
IPR022669 Domain Ribosomal protein L2, C-terminal
IPR014726 Domain Ribosomal protein L2, domain 3
IPR022666 Domain Ribosomal Proteins L2, RNA binding domain
IPR022671 Conserved_site Ribosomal protein L2, conserved site

2 Cross Referencess

Identifier
PTHR13691
PIRSF002158

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003735 IPR002171
GO:0006412 IPR002171
GO:0005622 IPR002171
GO:0005840 IPR002171

4 Ontology Annotations

GO Term Gene Name
GO:0003735 IPR002171
GO:0006412 IPR002171
GO:0005622 IPR002171
GO:0005840 IPR002171

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
170971 D8RF89 PAC:15409909 Selaginella moellendorffii 260  
137825 D8TEA9 PAC:15422913 Selaginella moellendorffii 287  
17231 D8S6Z5 PAC:15418536 Selaginella moellendorffii 144  
17971 D8R928 PAC:15401626 Selaginella moellendorffii 91  
evm.model.supercontig_25.175 PAC:16414773 Carica papaya 260  
evm.model.supercontig_6.233 PAC:16423413 Carica papaya 260  
evm.model.supercontig_9.275 PAC:16428174 Carica papaya 117  
29743.m000298 B9SK07 PAC:16807686 Ricinus communis 261  
29805.m001480 B9SGQ7 PAC:16809186 Ricinus communis 312  
29929.m004740 B9RMN5 PAC:16813979 Ricinus communis 111  
29949.m000118 B9T6J5 PAC:16814386 Ricinus communis 241  
30156.m001699 B9RPL9 PAC:16820830 Ricinus communis 261  
Cucsa.043460.1 A0A0A0KKM7 PAC:16953053 Cucumis sativus 260  
Cucsa.011520.1 PAC:16951438 Cucumis sativus 46  
Cucsa.053310.1 A0A0A0L7L1 PAC:16954299 Cucumis sativus 260  
Cucsa.245580.1 PAC:16971368 Cucumis sativus 304  
Cucsa.250010.1 PAC:16971597 Cucumis sativus 216  
orange1.1g045484m A0A067D7B3 PAC:18098124 Citrus sinensis 179  
orange1.1g037430m A0A067FUU5 PAC:18098598 Citrus sinensis 198  
orange1.1g027754m A0A067EHM1 PAC:18098214 Citrus sinensis 219  
orange1.1g027745m A0A067EHM1 PAC:18098215 Citrus sinensis 219  
orange1.1g027746m A0A067EHM1 PAC:18098216 Citrus sinensis 219  
orange1.1g024947m A0A067E951 PAC:18128096 Citrus sinensis 260  
orange1.1g043842m A0A067DTU1 PAC:18121245 Citrus sinensis 129  
orange1.1g047220m A0A067E5Q4 PAC:18121242 Citrus sinensis 128  
AT4G36130.1 Q42064 PAC:19648023 Arabidopsis thaliana 258  
ATCG00830.1 P56791 PAC:19637974 Arabidopsis thaliana 274  
ATMG00560.1 P93311 PAC:19643641 Arabidopsis thaliana 349  
ATCG01310.1 P56791 PAC:19638023 Arabidopsis thaliana 274  
AT3G51190.1 Q4PSL7 PAC:19659354 Arabidopsis thaliana 260  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11297922
            11290319
            11114498
            1579444