Protein Domain : IPR005880

Type:  Family Name:  Ribosomal protein L2, bacterial/organellar-type
Description:  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].The protein L2 is found in all ribosomes and is one of the best conserved proteins of this mega-dalton complex. L2 is elongated, exposing one end of the protein to the surface of the intersubunit interface of the 50 S subunit and is essential for the association of the ribosomal subunits and might participate in the binding and translocation of the tRNAs []. This entry represents bacterial, chloroplast and mitochondrial forms. Short Name:  Ribosomal_L2_bac/org-type
Paste the following link

0 Child Features

7 Contains

DB identifier Type Name
IPR012340 Domain Nucleic acid-binding, OB-fold
IPR014722 Domain Ribosomal protein L2 domain 2
IPR008991 Domain Translation protein SH3-like domain
IPR022669 Domain Ribosomal protein L2, C-terminal
IPR014726 Domain Ribosomal protein L2, domain 3
IPR022666 Domain Ribosomal Proteins L2, RNA binding domain
IPR022671 Conserved_site Ribosomal protein L2, conserved site

3 Cross Referencess

Identifier
PTHR13691:SF5
TIGR01171
MF_01320_B

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003723 IPR005880
GO:0003735 IPR005880
GO:0016740 IPR005880
GO:0006412 IPR005880
GO:0015934 IPR005880

5 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR005880
GO:0003735 IPR005880
GO:0016740 IPR005880
GO:0006412 IPR005880
GO:0015934 IPR005880

1 Parent Features

DB identifier Type Name
IPR002171 Family Ribosomal protein L2

790 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
137825 D8TEA9 PAC:15422913 Selaginella moellendorffii 287  
17231 D8S6Z5 PAC:15418536 Selaginella moellendorffii 144  
29949.m000118 B9T6J5 PAC:16814386 Ricinus communis 241  
Cucsa.250010.1 PAC:16971597 Cucumis sativus 216  
orange1.1g045484m A0A067D7B3 PAC:18098124 Citrus sinensis 179  
orange1.1g027754m A0A067EHM1 PAC:18098214 Citrus sinensis 219  
orange1.1g027745m A0A067EHM1 PAC:18098215 Citrus sinensis 219  
orange1.1g027746m A0A067EHM1 PAC:18098216 Citrus sinensis 219  
orange1.1g043842m A0A067DTU1 PAC:18121245 Citrus sinensis 129  
orange1.1g047220m A0A067E5Q4 PAC:18121242 Citrus sinensis 128  
ATCG00830.1 P56791 PAC:19637974 Arabidopsis thaliana 274  
ATCG01310.1 P56791 PAC:19638023 Arabidopsis thaliana 274  
Thhalv10028045m V4LWV2 PAC:20189391 Eutrema salsugineum 279  
Thhalv10001757m V4KMD4 PAC:20189177 Eutrema salsugineum 222  
Thhalv10001832m V4N1E9 PAC:20179501 Eutrema salsugineum 267  
Ciclev10022330m V4TZI4 PAC:20806915 Citrus clementina 200  
Ciclev10023703m V4TPL3 PAC:20809901 Citrus clementina 119  
Ciclev10023645m V4TZJ3 PAC:20811318 Citrus clementina 162  
Ciclev10016628m V4U0M9 PAC:20815818 Citrus clementina 219  
Lus10001687 PAC:23144378 Linum usitatissimum 223  
Potri.017G007700.1 U5FH70 PAC:26984161 Populus trichocarpa 208  
Potri.017G007700.2 PAC:26984162 Populus trichocarpa 206  
Potri.007G142200.2 PAC:27015408 Populus trichocarpa 213  
Potri.007G142200.1 U5G9F9 PAC:27015407 Populus trichocarpa 215  
Potri.013G138600.1 PAC:26994132 Populus trichocarpa 278  
Potri.013G143300.1 A0A2K1Y5M9 PAC:26994669 Populus trichocarpa 244  
Gorai.001G079400.1 A0A0D2PNE7 PAC:26821092 Gossypium raimondii 184  
Gorai.002G169400.1 A0A0D2NP66 PAC:26794319 Gossypium raimondii 142  
Gorai.007G372600.1 A0A0D2PKF7 PAC:26783797 Gossypium raimondii 142  
48359 I0YQJ8 PAC:27387845 Coccomyxa subellipsoidea C-169 348  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11297922
            11290319
            11114498
            11114255