Protein Domain : IPR001696

Type:  Family Name:  Voltage gated sodium channel, alpha subunit
Description:  Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in mostelectrically excitable cells []. They may exist in 3 states []: theresting state, where the channel is closed; the activated state, where the channel is open; and the inactivated state, where the channel is closedand refractory to opening. Several different structurally and functionally distinct isoforms are found in mammals, coded for by a multigene family, these being responsible for the different types of sodium ion currentsfound in excitable tissues. The structure of sodium channels is based on 4 internal repeats of a 6-helix bundle [] (in which 5 of the membrane-spanning segments are hydrophobic andthe other is positively charged), forming a 24-helical bundle. The charged segments are believed to be localised within clusters formed by their 5 hydrophobic neighbours: it is postulated that the charged domain may be the voltage sensor region, possibly moving outward on depolarisation, causing aconformational change. This model [] contrastswith another [], in which the TM segments are juxtaposedoctagonally. The basic structural motif (the 6-helix bundle) is also found in potassium and calcium channel alpha subunits.Cation channels are transport proteins responsible for the movement of cations through the membrane. These proteins contain 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. This entry represents alpha subunits of the voltage-gated Na+ channel superfamily. Short Name:  Na_channel_asu
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12 Child Features

DB identifier Type Name
IPR028812 Family Voltage gated sodium channel, alpha-7 subunit
IPR028814 Family Sodium channel protein para
IPR028817 Family Voltage gated sodium channel type 4, subunit alpha A
IPR028808 Family Voltage gated sodium channel, alpha-3 subunit
IPR028809 Family Voltage gated sodium channel, alpha-10 subunit
IPR028803 Family Voltage gated sodium channel, alpha-9 subunit
IPR028821 Family Voltage gated sodium channel, alpha-11 subunit
IPR028820 Family Sodium channel protein 60E
IPR028826 Family Voltage gated sodium channel, alpha-4 subunit
IPR008053 Family Voltage gated sodium channel, alpha-5 subunit
IPR008054 Family Voltage gated sodium channel, alpha-8 subunit
IPR008051 Family Voltage gated sodium channel, alpha-1 subunit

3 Contains

DB identifier Type Name
IPR005821 Domain Ion transport domain
IPR000048 Binding_site IQ motif, EF-hand binding site
IPR010526 Domain Sodium ion transport-associated

2 Cross Referencess

Identifier
PTHR10037:SF132
PR00170

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005248 IPR001696
GO:0006814 IPR001696
GO:0001518 IPR001696

3 Ontology Annotations

GO Term Gene Name
GO:0005248 IPR001696
GO:0006814 IPR001696
GO:0001518 IPR001696

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1323284
            6209577
            1317577