Protein Domain : IPR028809

Type:  Family Name:  Voltage gated sodium channel, alpha-10 subunit
Description:  Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [, ].Nav1.8 (sodium channel protein type 10 subunit alpha) is a tetrodotoxin-resistant sodium channel isoform that plays a role in neuropathic pain mechanism [, , , ]. Short Name:  Na_channel_a10su
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10037:SF23

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005248 IPR028809
GO:0006814 IPR028809
GO:0019233 IPR028809
GO:0001518 IPR028809

4 Ontology Annotations

GO Term Gene Name
GO:0005248 IPR028809
GO:0006814 IPR028809
GO:0019233 IPR028809
GO:0001518 IPR028809

1 Parent Features

DB identifier Type Name
IPR001696 Family Voltage gated sodium channel, alpha subunit

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10798388
            16382098
            9839820
            8538791
            8626372
            12514212