Protein Domain : IPR028808

Type:  Family Name:  Voltage gated sodium channel, alpha-3 subunit
Description:  Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [, ].This entry represents Nav1.3 (sodium channel protein type 3 subunit alpha). It plays an important role in neuropathic pain []. Short Name:  Na_channel_a3su

0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10037:SF200

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005248 IPR028808
GO:0006814 IPR028808
GO:0001518 IPR028808

3 Ontology Annotations

GO Term Gene Name
GO:0005248 IPR028808
GO:0006814 IPR028808
GO:0001518 IPR028808

1 Parent Features

DB identifier Type Name
IPR001696 Family Voltage gated sodium channel, alpha subunit

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10798388
            16382098
            24234845