| Type: | Family | Name: | Voltage gated sodium channel, alpha-9 subunit |
| Description: | Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [, ].Sodium channel protein type 9 subunit alpha (also known as Nav1.7 or SCN9A) is strongly expressed in nociceptive neurons and plays a role in pain mechanisms, especially in the development of inflammatory pain [, , ]. It interacts with the ubiquitin-protein ligases Nedd4 and Nedd4-2, known to regulate receptors and ion transporters []. | Short Name: | SCN9A |
| GO Term | Gene Name |
|---|---|
| GO:0005248 | IPR028803 |
| GO:0006954 | IPR028803 |
| GO:0048266 | IPR028803 |
| GO:0001518 | IPR028803 |
| GO Term | Gene Name |
|---|---|
| GO:0005248 | IPR028803 |
| GO:0006954 | IPR028803 |
| GO:0048266 | IPR028803 |
| GO:0001518 | IPR028803 |
| DB identifier | Type | Name |
|---|---|---|
| IPR001696 | Family | Voltage gated sodium channel, alpha subunit |
