Protein Domain : IPR001314

Type:  Family Name:  Peptidase S1A, chymotrypsin-type
Description:  This group of serine peptidases and non-peptidase homologues belong to the MEROPS peptidase family S1, subfamily S1A (chymotrypsin subfamily, clan PA(S)). The type example being chymotrypsin A from Bos taurus(Bovine). Members of the chymotrypsin family may occasionally function intracellularly (for example, the intracellular digestion of bacteria in neutrophils), butmost function extracellularly, for example in roles such as food digestion, fibrinolysis and complement activation [].The essential catalytic unit of the chymotrypsin family is around 220 amino acids in length, although the protein may be extended at theN terminus with unrelated sequences, often containing modules. They are rarely extended at the C terminus: exceptions include acrosin, complement component C2, and coagulation factor X, which has a 16 residue extension that is removed upon activation []. Short Name:  Peptidase_S1A
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15 Child Features

DB identifier Type Name
IPR003966 Family Prothrombin/thrombin
IPR011360 Family Complement B/C2
IPR017118 Family Peptidase S1A, matriptase-2
IPR017324 Family Transmembrane protease serine 9
IPR011163 Family Peptidase S1A, enteropeptidase
IPR017327 Family Peptidase S1A, TMPRSS13
IPR014394 Family Coagulation factor XIIa/hepatocyte growth factor activator
IPR026280 Family Tissue plasminogen activator
IPR024174 Family Hepatocyte growth factor-like
IPR024175 Family Peptidase S1A, complement C1r/C1S/mannan-binding
IPR017329 Family Peptidase S1A, HAT/DESC1
IPR012224 Family Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR012267 Family Peptidase S1A, acrosin
IPR008292 Family Haptoglobin
IPR017326 Family Peptidase S1A, polyserase-2

10 Contains

DB identifier Type Name
IPR018992 Domain Thrombin light chain
IPR000001 Domain Kringle
IPR000294 Domain Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000177 Domain Apple domain
IPR006604 Domain Disulphide knot CLIP
IPR022700 Domain Proteinase, regulatory CLIP domain
IPR018056 Conserved_site Kringle, conserved site
IPR018114 Active_site Peptidase S1, trypsin family, active site
IPR000083 Domain Fibronectin, type I
IPR015352 Domain Hepsin, SRCR domain

1 Cross References

Identifier
PR00722

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004252 IPR001314
GO:0006508 IPR001314

2 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR001314
GO:0006508 IPR001314

0 Parent Features

34 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
32476.m000026 B9TEG9 PAC:16825440 Ricinus communis 278  
13559 C1MGJ4 PAC:27345704 Micromonas pusilla CCMP1545 214  
51288 C1N174 PAC:27340201 Micromonas pusilla CCMP1545 552  
11334 C1N302 PAC:27349265 Micromonas pusilla CCMP1545 194  
46264 C1MHU1 PAC:27345714 Micromonas pusilla CCMP1545 2353  
76323 C1FIY1 PAC:27399737 Micromonas sp RCC299 244  
7168 A4S4W9 PAC:27420495 Ostreococcus lucimarinus 209  
Cre10.g464400.t1.1 A0A2K3DC46 PAC:30790433 Chlamydomonas reinhardtii 509  
Cre17.g740600.t2.1 A0A2K3CRQ3 PAC:30782340 Chlamydomonas reinhardtii 1117  
Cre17.g740600.t1.2 A0A2K3CRQ3 PAC:30782339 Chlamydomonas reinhardtii 1117  
Cre06.g267750.t1.2 A0A2K3DN45 PAC:30778709 Chlamydomonas reinhardtii 649  
Zosma9953g00010.1 A0A0K9NHF9 PAC:33165368 Zostera marina 263  
Pum0380s0004.1.p A0A1X6NWU5 PAC:38008086 Porphyra umbilicalis 509  
Pum0371s0022.1.p A0A1X6NX20 PAC:38015298 Porphyra umbilicalis 309  
Pum0176s0032.1.p A0A1X6P7Q8 PAC:38008480 Porphyra umbilicalis 326  
Pum0219s0030.1.p A0A1X6P505 PAC:38006499 Porphyra umbilicalis 528  
Pum0098s0065.1.p A0A1X6PD52 PAC:38017138 Porphyra umbilicalis 311  
Pum0098s0060.1.p A0A1X6PDC5 PAC:38017147 Porphyra umbilicalis 310  
Pum0138s0004.1.p A0A1X6P9X9 PAC:38013593 Porphyra umbilicalis 569  
Pum0320s0018.1.p A0A1X6NZA3 PAC:38005849 Porphyra umbilicalis 588  
Pum0031s0055.1.p A0A1X6PJM5 PAC:38017622 Porphyra umbilicalis 711  
Pum0077s0030.1.p A0A1X6PEZ6 PAC:38010429 Porphyra umbilicalis 637  
Pum0292s0017.1.p A0A1X6P0I5 PAC:38005819 Porphyra umbilicalis 308  
Pum0350s0012.1.p A0A1X6NXP7 PAC:38015439 Porphyra umbilicalis 377  
Pum0350s0006.1.p A0A1X6NXQ7 PAC:38015438 Porphyra umbilicalis 377  
Pum0058s0023.1.p A0A1X6PH15 PAC:38011066 Porphyra umbilicalis 711  
Pum0055s0034.1.p A0A1X6PHJ1 PAC:38014611 Porphyra umbilicalis 557  
Pum0738s0003.1.p A0A1X6NPF7 PAC:38007233 Porphyra umbilicalis 498  
Pum0686s0001.1.p A0A1X6NPX5 PAC:38009799 Porphyra umbilicalis 369  
Cz06g31110.t1 PAC:38248769 Chromochloris zofingiensis 701  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7845208