Protein Domain : IPR003966

Type:  Family Name:  Prothrombin/thrombin
Description:  Thrombin belongs to the MEROPS peptidase family S1, subfamily S1A.Prothrombin consists of an N-terminal gamma-carboxyglutamate (GLA) domain, two kringle domains, and the S1A peptidase catalytic domain. The cleavage of prothrombin to thrombin is catalysed by the prothrombinase enzyme complex that consists of serine protease factor Xa, cofactor Va, phospholipids and calcium. Prothromin is cleaved by this enzyme into three fragments: fragment 1 (F1) consits of the GLA domain and the first Kringle domain; fragment 2 (F2) consists of the second Kringle domain; and thrombin (peptidase catalytic domain). F1 facilitates calcium-dependent binding of the proenzyme to phospholipid surfaces. F2 interacts with factor Va, and once it is released from prothrombin, it can bind thrombin to influence its function [].Thrombin is a member of the trypsin family of S1 peptidases. It catalyses the preferential cleavage of arginine-lysine bonds, converting fibrinogen to fibrin, and releasing fibrinopeptides A and B. Thrombin can itself cleave the N-terminal fragment (fragment 1) of prothrombin, prior to its activation by factor Xa. Its effects are mediated by the thrombin receptor. Structures of the thrombin A-chain [] and B-chain [] have been determined. The most conserved portions of the B chain are the active-site residues and adjacent amino acids, the B loop, and the primary substrate-binding region []. The extent of sequence similarity between species and the conservation of many of the functional/structural motifs suggests that, in addition to their role in blood coagulation, vertebrate thrombins may play an important role in the general mechanisms of wound repair []. Short Name:  Prothrombin/thrombin
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0 Child Features

7 Contains

DB identifier Type Name
IPR009003 Domain Peptidase S1, PA clan
IPR001254 Domain Serine proteases, trypsin domain
IPR013806 Domain Kringle-like fold
IPR018992 Domain Thrombin light chain
IPR000001 Domain Kringle
IPR018056 Conserved_site Kringle, conserved site
IPR018114 Active_site Peptidase S1, trypsin family, active site

2 Cross Referencess

Identifier
PIRSF001149
PR01505

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004252 IPR003966
GO:0005509 IPR003966
GO:0006508 IPR003966
GO:0007596 IPR003966

4 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR003966
GO:0005509 IPR003966
GO:0006508 IPR003966
GO:0007596 IPR003966

1 Parent Features

DB identifier Type Name
IPR001314 Family Peptidase S1A, chymotrypsin-type

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2583108
            10051558
            1557383
            9535876