Protein Domain : IPR018992

Type:  Domain Name:  Thrombin light chain
Description:  Thrombin is a Na+-activated, allosteric serine protease that functions in blood homeostasis, inflammation and wound healing []. Thrombin (or coagulation factor II) is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, and (in complex with thrombomodulin) protein C []. Sodium binding is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme, but is dispensablefor cleavage of the anticoagulant protein C []. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin. Short Name:  Thrombin_light_chain
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF09396
G3DSA:4.10.140.10

2 Found Ins

DB identifier Type Name
IPR001314 Family Peptidase S1A, chymotrypsin-type
IPR003966 Family Prothrombin/thrombin

4 GO Annotations

GO Term Gene Name
GO:0004252 IPR018992
GO:0006508 IPR018992
GO:0007596 IPR018992
GO:0005576 IPR018992

4 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR018992
GO:0006508 IPR018992
GO:0007596 IPR018992
GO:0005576 IPR018992

0 Parent Features

212 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cucsa.385650.1 A0A0A0KAX7 PAC:16982604 Cucumis sativus 228  
Cucsa.123240.1 PAC:16961568 Cucumis sativus 70  
orange1.1g043224m A0A067H0F6 PAC:18091608 Citrus sinensis 516  
AT2G15930.1 Q9XIM4 PAC:19639255 Arabidopsis thaliana 58  
Lus10018802 PAC:23178427 Linum usitatissimum 158  
Gorai.010G092000.1 A0A0D2UBI1 PAC:26758589 Gossypium raimondii 282  
Thecc1EG000126t1 A0A061DF81 PAC:27436436 Theobroma cacao 249  
Thecc1EG045504t1 A0A061FZ79 PAC:27442649 Theobroma cacao 114  
Migut.N01165.1.p PAC:28923555 Mimulus guttatus 461  
Brara.A03393.1.p A0A398AZ38 PAC:30637384 Brassica rapa FPsc 240  
Traes_3B_018CE454F.1 W5CP75 PAC:31739976 Triticum aestivum 214  
Manes.08G106900.1.p A0A2C9VF68 PAC:32331862 Manihot esculenta 439  
Pahal.E01391.1 PAC:32498460 Panicum hallii 195  
Sphfalx0238s0041.1.p PAC:32612629 Sphagnum fallax 201  
Sevir.5G344800.1.p A0A4U6ULI2 PAC:32674190 Setaria viridis 212  
Seita.5G340600.1.p A0A368RBX6 PAC:32681464 Setaria italica 212  
Bradi2g51800.5.p I1HS98 PAC:32773836 Brachypodium distachyon 213  
Bradi2g51800.6.p I1HS98 PAC:32773837 Brachypodium distachyon 213  
Bradi2g51800.2.p A0A0Q3IWR3 PAC:32773833 Brachypodium distachyon 265  
Bradi2g51800.4.p I1HS98 PAC:32773835 Brachypodium distachyon 213  
Bradi2g51800.1.p I1HS98 PAC:32773834 Brachypodium distachyon 213  
Aco014399.1 A0A199UYU5 PAC:33048876 Ananas comosus 214  
LOC_Os01g57260.1 PAC:33122685 Oryza sativa 213  
Brdisv1Per11021492m.p I1HS98 PAC:33216025 Brachypodium distachyon Per1 213  
Brdisv1Uni21020330m.p I1HS98 PAC:33277474 Brachypodium distachyon Uni2 213  
Brdisv1Bd3-1_r1016508m.p PAC:33315461 Brachypodium distachyon Bd3-1 213  
Brdisv1BdTR7a1021271m.p PAC:33361693 Brachypodium distachyon BdTR7a 241  
Brdisv1BdTR7a1021270m.p PAC:33361694 Brachypodium distachyon BdTR7a 229  
Brdisv1BdTR7a1021269m.p PAC:33361695 Brachypodium distachyon BdTR7a 215  
Brdisv1Koz-11021620m.p I1HS98 PAC:33410028 Brachypodium distachyon Koz-1 213  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18329094
            18282807
            15656349