Protein Domain : IPR000001

Type:  Domain Name:  Kringle
Description:  Kringles are autonomous structural domains, found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity [, , ]. Kringle domains [, , ] are characterised by a triple loop, 3-disulphide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogen activator, which are serine proteases belonging to MEROPS peptidase family S1A. Short Name:  Kringle
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0 Child Features

1 Contains

DB identifier Type Name
IPR018056 Conserved_site Kringle, conserved site

3 Cross Referencess

Identifier
PF00051
PS50070
SM00130

5 Found Ins

DB identifier Type Name
IPR001314 Family Peptidase S1A, chymotrypsin-type
IPR003966 Family Prothrombin/thrombin
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR014394 Family Coagulation factor XIIa/hepatocyte growth factor activator
IPR017076 Family Kremen

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR013806 Domain Kringle-like fold

13 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
46264 C1MHU1 PAC:27345714 Micromonas pusilla CCMP1545 2353  
85746 C1FIA1 PAC:27397322 Micromonas sp RCC299 153  
9854 A4RY14 PAC:27416432 Ostreococcus lucimarinus 66  
9500 A4RY13 PAC:27416597 Ostreococcus lucimarinus 74  
93844 A4S8Y6 PAC:27415949 Ostreococcus lucimarinus 856  
Cre05.g240900.t2.1 A0A2K3DT70 PAC:30783173 Chlamydomonas reinhardtii 1202  
Cre05.g240900.t1.2 A0A2K3DT71 PAC:30783172 Chlamydomonas reinhardtii 1210  
Cz11g21150.t1 PAC:38237476 Chromochloris zofingiensis 945  
Sialb.0170s0071.1.p PAC:39593874 Sinapis alba 1032  
arahy.Tifrunner.gnm1.ann1.0PHB1J.1 PAC:42607422 Arachis hypogaea 300  
Sialb.2798s0007.1.p PAC:45622440 Sinapis alba 1032  
Sialb.0064s0355.2.p PAC:45625766 Sinapis alba 974  
Sialb.0064s0355.1.p PAC:45625765 Sinapis alba 974  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3891096
            6373375
            3886654
            1879523
            2157850
            3131537