Protein Domain : IPR000294

Type:  Domain Name:  Gamma-carboxyglutamic acid-rich (GLA) domain
Description:  The GLA (gamma-carboxyglutamic acid-rich) domain contains glutamate residues that have been post-translationally modified by vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla) [, , ]. All glutamic acid (Glu) residues present in the GLA domain are potential carboxylation sites; in coagulation proteins, all Gu residues are modified to Gla, while in osteocalcin and matrix Gla proteins only some Glu residues are modified to Gla. The GLA domain is responsible for the high-affinity binding of calcium ions. It starts at the N-terminal extremity of the mature form of proteins and ends with a conserved aromatic residue; a conserved Gla-x(3)-Gla-x-Cys motif [] is found in the middle of the domain which seems to be important for substrate recognition by the carboxylase.The 3D structure of the GLA domain has been solved [, ]. Calcium ions induce conformational changes in the GLA domain that and are necessary for the proper folding of the GLA domain. A common structural feature of functional GLA domains is the clustering of N-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell surface membrane []. Proteins known to contain a GLA domain include []:Coagulation factor X []Coagulation factor VII []Coagulation factor IX []Coagulation factor XIV (vitamin K-dependent protein C) []Vitamin K-dependent protein S []Vitamin K-dependent protein Z []ProthrombinTransthyretinOsteocalcin (also known as bone-Gla protein, BGP)Matrix Gla protein (MGP) []Inter-alpha-trypsin inhibitor heavy chain H2Growth arrest-specific protein 6 (Gas-6) [] Short Name:  GLA_domain
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0 Child Features

0 Contains

6 Cross Referencess

Identifier
PF00594
PR00001
PS00011
PS50998
SM00069
SSF57630

2 Found Ins

DB identifier Type Name
IPR001314 Family Peptidase S1A, chymotrypsin-type
IPR012224 Family Peptidase S1A, coagulation factor VII/IX/X/C/Z

2 GO Annotations

GO Term Gene Name
GO:0005509 IPR000294
GO:0005576 IPR000294

2 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR000294
GO:0005576 IPR000294

0 Parent Features

12 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Migut.J01598.1.p A0A022R4Y2 PAC:28941770 Mimulus guttatus 245  
Traes_5DL_A57FA68FA.2 PAC:32024295 Triticum aestivum 33  
Zm00008a034405_P01 PAC:37179813 Zea mays PH207 61  
Pavir.1NG331000.2.p PAC:37614446 Panicum virgatum 1303  
Pavir.1NG331000.1.p PAC:37614445 Panicum virgatum 1303  
Oeu005033.1 PAC:37707334 Olea europaea 176  
Thint.03G0327400.2.p PAC:40923709 Thinopyrum intermedium 126  
Pavir.1NG331000.1.p PAC:41587279 Panicum virgatum 1303  
Pavir.1NG331000.2.p PAC:41587281 Panicum virgatum 1303  
Pavir.1NG331000.5.p PAC:41587283 Panicum virgatum 822  
Pavir.1NG331000.4.p PAC:41587282 Panicum virgatum 1022  
Pavir.1NG331000.3.p PAC:41587280 Panicum virgatum 1303  

15 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3317405
            7713897
            8663165
            18374189
            18374194
            11818531
            18373251
            17723139
            2403355
            18369157
            9163328
            16156662
            18642129
            18680528
            16460467