Protein Domain : IPR013783

Type:  Domain Name:  Immunoglobulin-like fold
Description:  This entry represents domains with an immunoglobulin-like (Ig-like) fold, which consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals, occurring in a variety of different proteins. These domains are often involved in interactions, commonly with other Ig-like domains via their beta-sheets [, , , ]. Domains within this fold-family share the same structure, but can diverge with respect to their sequence. Based on sequence, Ig-like domains can be classified as V-set domains (antibody variable domain-like), C1-set domains (antibody constant domain-like), C2-set domains, and I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example, in the human T-cell receptor antigen CD2, domain 1 (D1) is a V-set domain, while domain 2 (D2) is a C2-set domain, both domains having the same Ig-like fold [].Domains with an Ig-like fold can be found in many, diverse proteins in addition to immunoglobulin molecules. For example, Ig-like domains occur in several different types of receptors (such as various T-cell antigen receptors), several cell adhesion molecules, MHC class I and II antigens, as well as the hemolymph protein hemolin, and the muscle proteins titin, telokin and twitchin. Short Name:  Ig-like_fold
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4 Child Features

DB identifier Type Name
IPR003961 Domain Fibronectin type III
IPR007110 Domain Immunoglobulin-like domain
IPR001102 Domain Transglutaminase, N-terminal
IPR024303 Domain Natural killer cell receptor 2B4, immunoglobulin domain

17 Contains

DB identifier Type Name
IPR004193 Domain Glycoside hydrolase, family 13, N-terminal
IPR017868 Repeat Filamin/ABP280 repeat-like
IPR002909 Domain IPT domain
IPR001298 Repeat Filamin/ABP280 repeat
IPR013098 Domain Immunoglobulin I-set
IPR004197 Domain Glycoside hydrolase, family 9, N-terminal, Ig-like
IPR013151 Domain Immunoglobulin
IPR005102 Domain Carbohydrate binding X2 domain
IPR005536 Domain Peptidase C25, Ig-like domain
IPR008424 Domain Immunoglobulin C2-set
IPR015274 Domain CD4, extracellular
IPR003006 Conserved_site Immunoglobulin/major histocompatibility complex, conserved site
IPR015169 Domain Adhesion molecule, immunoglobulin-like
IPR015370 Domain Domain of unknown function DUF1968
IPR003987 Domain Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
IPR003988 Domain Intercellular adhesion molecule
IPR013768 Domain Intercellular adhesion molecule, N-terminal

1 Cross References

Identifier
G3DSA:2.60.40.10

39 Found Ins

DB identifier Type Name
IPR006407 Family 1,4-alpha-glucan-branching enzyme, GlgB
IPR015202 Domain Domain of unknown function DUF1929
IPR011837 Family Glycogen debranching enzyme, GlgX type
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR015621 Family Interleukin-1 receptor family
IPR008465 Family Dystroglycan
IPR016332 Family Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor
IPR016248 Family Fibroblast growth factor receptor family
IPR011838 Domain Pullulanase, extracellular
IPR011840 Domain Pullulanase, type I
IPR012768 Family Malto-oligosyltrehalose trehalohydrolase
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR018250 Family Neuregulin-1
IPR016663 Family Myelin-oligodendrocyte glycoprotein
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR008291 Family Glucoamylase, starch-binding
IPR020675 Family Myosin light chain kinase-related
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific
IPR013540 Domain Chitinase A N-terminal
IPR015171 Domain Cyclomaltodextrinase, N-terminal
IPR008366 Family Nuclear factor of activated T cells (NFAT)
IPR015646 Family Nuclear factor of activated T-cells 5
IPR015647 Family Nuclear factor of activated T-cells 1
IPR000451 Family NF-kappa-B/Dorsal
IPR011363 Family Dorsal/Dif protein
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
65145 D8RF42 PAC:15403205 Selaginella moellendorffii 348  
412212 D8RKG0 PAC:15409931 Selaginella moellendorffii 1140  
8796 D8RKP0 PAC:15407482 Selaginella moellendorffii 79  
441651 D8RLP0 PAC:15409431 Selaginella moellendorffii 550  
98697 D8RNL0 PAC:15415354 Selaginella moellendorffii 269  
413728 D8RQ13 PAC:15416696 Selaginella moellendorffii 330  
413959 D8RR64 PAC:15418337 Selaginella moellendorffii 537  
414115 D8RRP5 PAC:15415064 Selaginella moellendorffii 322  
414113 D8RRP3 PAC:15415060 Selaginella moellendorffii 652  
34445 D8RS38 PAC:15403319 Selaginella moellendorffii 255  
442281 D8RS80 PAC:15409371 Selaginella moellendorffii 431  
442479 D8RTS2 PAC:15410931 Selaginella moellendorffii 1255  
415024 D8RUD2 PAC:15417199 Selaginella moellendorffii 407  
33314 D8RW73 PAC:15421874 Selaginella moellendorffii 387  
442814 D8RWC6 PAC:15413910 Selaginella moellendorffii 884  
405262 D8QWS8 PAC:15411654 Selaginella moellendorffii 425  
438530 D8QWK1 PAC:15421792 Selaginella moellendorffii 516  
416480 D8RZE9 PAC:15423216 Selaginella moellendorffii 1365  
416436 D8RZ98 PAC:15423107 Selaginella moellendorffii 381  
64073 D8R0R6 PAC:15421907 Selaginella moellendorffii 469  
444263 D8S8I1 PAC:15415216 Selaginella moellendorffii 995  
420948 D8SDM9 PAC:15416701 Selaginella moellendorffii 298  
266879 D8R0S4 PAC:15411501 Selaginella moellendorffii 346  
227648 D8R6G4 PAC:15406280 Selaginella moellendorffii 208  
407438 D8R5L7 PAC:15418976 Selaginella moellendorffii 1810  
89852 D8RAW4 PAC:15412479 Selaginella moellendorffii 535  
89622 D8RBG4 PAC:15410886 Selaginella moellendorffii 581  
17213 D8RB41 PAC:15418491 Selaginella moellendorffii 177  
231119 D8RAV9 PAC:15414492 Selaginella moellendorffii 520  
68032 D8RBN5 PAC:15411305 Selaginella moellendorffii 180  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15327963
            10698639
            7932691
            10436082
            7994575