Protein Domain : IPR013098

Type:  Domain Name:  Immunoglobulin I-set
Description:  The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ), C1-set (constant-1; ), C2-set (constant-2; ) and I-set (intermediate; ) []. Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns [, ].Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system []. This entry represents I-set domains, which are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1 [], and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis []. Short Name:  Ig_I-set
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0 Child Features

2 Contains

DB identifier Type Name
IPR003599 Domain Immunoglobulin subtype
IPR003598 Domain Immunoglobulin subtype 2

1 Cross References

Identifier
PF07679

20 Found Ins

DB identifier Type Name
IPR013783 Domain Immunoglobulin-like fold
IPR007110 Domain Immunoglobulin-like domain
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR004076 Family Interleukin-1 receptor type 1
IPR016248 Family Fibroblast growth factor receptor family
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR018250 Family Neuregulin-1
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR011390 Family Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
IPR020682 Family Obscurin-myosin light chain kinase
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR009138 Family Neural cell adhesion
IPR009135 Family Vascular endothelial growth factor receptor 1 (VEGFR1)
IPR009137 Family Vascular endothelial growth factor receptor 3 (VEGFR3)
IPR009151 Family Basigin
IPR003989 Family Vascular cell adhesion molecule-1

0 GO Annotation

0 Ontology Annotations

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre12.g495350.t1.1 A0A2K3D211 PAC:30792464 Chlamydomonas reinhardtii 1404  
Dusal.0836s00004.1.p PAC:33196403 Dunaliella salina 774  
Cz02g26100.t1 PAC:38247170 Chromochloris zofingiensis 1006  
Vocar.0031s0027.1.p PAC:32890060 Volvox carteri 1391  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11377196
            9417933
            15327963
            10698639
            10830169
            16369100