Protein Domain : IPR003599

Type:  Domain Name:  Immunoglobulin subtype
Description:  The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ), C1-set (constant-1; ), C2-set (constant-2; ) and I-set (intermediate; ) []. Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns [, ].Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system []. This subfamily includes:Cell surface receptors containing an immunoglobin domain.Killer cell inhibitory receptors.Oprin a snake venom metalloproteinase inhibitor from Didelphis marsupialis(Southern opossum) [], which belongs to MEROPS inhibitor family I43, clan I- [].Oprin homologues. Short Name:  Ig_sub
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0 Child Features

2 Contains

DB identifier Type Name
IPR013151 Domain Immunoglobulin
IPR015274 Domain CD4, extracellular

1 Cross References

Identifier
SM00409

25 Found Ins

DB identifier Type Name
IPR007110 Domain Immunoglobulin-like domain
IPR013098 Domain Immunoglobulin I-set
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR004076 Family Interleukin-1 receptor type 1
IPR004077 Family Interleukin-1 receptor type II
IPR004078 Family Interleukin-1 binding protein
IPR015621 Family Interleukin-1 receptor family
IPR016332 Family Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor
IPR015513 Family Semaphorin 3E
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR011390 Family Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR009135 Family Vascular endothelial growth factor receptor 1 (VEGFR1)
IPR009137 Family Vascular endothelial growth factor receptor 3 (VEGFR3)
IPR009151 Family Basigin
IPR000973 Family T-cell surface antigen CD4
IPR000920 Family Myelin P0 protein-related
IPR008056 Family Tapasin
IPR003989 Family Vascular cell adhesion molecule-1
IPR008096 Family Cytotoxic T-lymphocyte antigen 4
IPR015468 Family CD8 alpha subunit
IPR008664 Domain LISCH7
IPR015714 Family Lymphocyte function associated antigen 3

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre12.g495350.t1.1 A0A2K3D211 PAC:30792464 Chlamydomonas reinhardtii 1404  
Cz02g26100.t1 PAC:38247170 Chromochloris zofingiensis 1006  
Vocar.0031s0027.1.p PAC:32890060 Volvox carteri 1391  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14705960
            11377196
            9417933
            15327963
            10698639
            10779682