Protein Domain : IPR003961

Type:  Domain Name:  Fibronectin type III
Description:  Fibronectin is a dimeric glycoprotein composed of disulfide-linked subunits with a molecular weight of 220-250 kDa each. It is involved in cell adhesion,cell morphology, thrombosis, cell migration, and embryonic differentiation. Fibronectin is a modular protein composed of homologous repeats of three prototypical types of domains known as types I, II, and III [].Fibronectin type-III (FN3) repeats are both the largest and the most common of the fibronectin subdomains. Domains homologous to FN3 repeats have been found in various animal protein families including other extracellular-matrixmolecules, cell-surface receptors, enzymes, and muscle proteins []. Structures of individual FN3 domains have revealed a conserved beta sandwich fold with one beta sheet containing four strands and the other sheet containing three strands (see for example {PDB:1TEN}) []. This fold is topologically very similar to that of Ig-like domains, with a notable difference being the lack of a conserved disulfide bond in FN3 domains. Distinctive hydrophobic core packing and the lack of detectablesequence homology between immunoglobulin and FN3 domains suggest, however, that these domains are not evolutionarily related [].FN3 exhibits functional as well as structural modularity. Sites of interaction with other molecules have been mapped to short stretch of amino acids such as the Arg-Gly-Asp (RGD) sequence found in various FN3 domains. The RGD sequences is involved in interactions with integrin. Small peptides containing the RGD sequence can modulate a variety of cell adhesion invents associated with thrombosis, inflammation, and tumor metastasis. These properties have led to the investigation of RGD peptides and RGD peptide analogs as potential therapeutic agents []. Short Name:  FN3_dom
Paste the following link

0 Child Features

4 Contains

DB identifier Type Name
IPR003528 Conserved_site Long hematopoietin receptor, single chain, conserved site
IPR003529 Conserved_site Long hematopoietin receptor, Gp130 family 2, conserved site
IPR003531 Conserved_site Short hematopoietin receptor, family 1, conserved site
IPR003530 Conserved_site Long hematopoietin receptor, soluble alpha chain, conserved site

5 Cross Referencess

Identifier
PF00041
PF01108
PS50853
SM00060
SSF49265

15 Found Ins

DB identifier Type Name
IPR016335 Family Receptor-type tyrosine-protein phosphatase C
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR016257 Family Ephrin receptor type-A /type-B
IPR016669 Family Interferon alpha/beta receptor 1
IPR012013 Family Integrin beta-4 subunit
IPR014390 Family Acid phosphatase, Aspergillus type
IPR020682 Family Obscurin-myosin light chain kinase
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR009167 Family Erythropoietin receptor
IPR015528 Family Interleukin-12 beta
IPR019326 Family Protein of unknown function DUF2369
IPR011365 Family Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
IPR015752 Family Leptin receptor

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR003961

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR003961

1 Parent Features

DB identifier Type Name
IPR013783 Domain Immunoglobulin-like fold

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
442479 D8RTS2 PAC:15410931 Selaginella moellendorffii 1255  
415023 D8RUD1 PAC:15417198 Selaginella moellendorffii 679  
442814 D8RWC6 PAC:15413910 Selaginella moellendorffii 884  
444263 D8S8I1 PAC:15415216 Selaginella moellendorffii 995  
227648 D8R6G4 PAC:15406280 Selaginella moellendorffii 208  
evm.model.supercontig_1021.1 PAC:16404868 Carica papaya 560  
evm.model.supercontig_46.59 PAC:16420526 Carica papaya 474  
29763.m000194 B9SYG7 PAC:16808160 Ricinus communis 710  
29848.m004695 B9RPB3 PAC:16811350 Ricinus communis 725  
32769.m000029 B9TH10 PAC:16825550 Ricinus communis 170  
Cucsa.081150.1 A0A0A0LUM5 PAC:16956294 Cucumis sativus 738  
Cucsa.081150.2 A0A0A0LUM5 PAC:16956295 Cucumis sativus 738  
Cucsa.089290.1 PAC:16957120 Cucumis sativus 713  
Cucsa.116250.2 A0A0A0LHY8 PAC:16960537 Cucumis sativus 647  
Cucsa.116250.1 PAC:16960536 Cucumis sativus 718  
Cucsa.160540.1 PAC:16965366 Cucumis sativus 588  
Cucsa.235710.1 PAC:16970428 Cucumis sativus 653  
Cucsa.235710.2 PAC:16970429 Cucumis sativus 652  
orange1.1g041493m A0A067GRB5 PAC:18107754 Citrus sinensis 619  
orange1.1g004859m PAC:18095261 Citrus sinensis 727  
orange1.1g004853m PAC:18095260 Citrus sinensis 727  
orange1.1g004540m A0A067DZ08 PAC:18110831 Citrus sinensis 746  
orange1.1g004714m A0A067DQM6 PAC:18110833 Citrus sinensis 734  
orange1.1g004717m A0A067DQM6 PAC:18110832 Citrus sinensis 734  
orange1.1g005110m A0A067DXX4 PAC:18110834 Citrus sinensis 714  
AT4G30200.1 Q9SUM4 PAC:19646766 Arabidopsis thaliana 685  
AT4G30200.4 Q9SUM4 PAC:19646767 Arabidopsis thaliana 624  
AT4G30200.2 Q9SUM4 PAC:19646764 Arabidopsis thaliana 714  
AT4G30200.3 Q9SUM4 PAC:19646765 Arabidopsis thaliana 702  
AT5G57380.1 Q9FIE3 PAC:19668880 Arabidopsis thaliana 620  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1409594
            1279805
            8548820
            6218503