| Type: | Family | Name: | Interleukin-12 beta |
| Description: | Interleukins are a group of cytokines that have important roles in cell growth, differentiation, and motility, and in the functioning of the immune system.Interleukin-12 (also known as natural killer cell stimulatory factor, and cytotoxic lymphocyte maturation factor) is a 75 kDa heterodimer composed of two genetically unrelated subunits - an alpha chain (p35 subunit) and a beta chain (p40 subunit). Production of the cytokine plays an important role in the generation of cell-mediated immunity against many infectious pathogens []. The interluekin-12 beta chain also associates withinterleukin-23 alpha to form interleukin-23 [], a proinflammatory cytokine that is overexpressed in and around tumour tissues, where it induces local inflammation and promotes tumour development [].This entry represents Interleukin-12 beta. | Short Name: | IL-12_beta |
| DB identifier | Type | Name |
|---|---|---|
| IPR013783 | Domain | Immunoglobulin-like fold |
| IPR003961 | Domain | Fibronectin type III |
| IPR007110 | Domain | Immunoglobulin-like domain |
| IPR003598 | Domain | Immunoglobulin subtype 2 |
| IPR019482 | Domain | Interleukin-12 beta, central domain |
| IPR003530 | Conserved_site | Long hematopoietin receptor, soluble alpha chain, conserved site |
