| Type: | Domain | Name: | HRDC-like |
| Description: | The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed alpha-hairpin subdomains, and is involved in interactions with DNA and protein. The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins []. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation alpha-hairpin [, ]. | Short Name: | HRDC-like |
| DB identifier | Type | Name |
|---|---|---|
| IPR005574 | Family | RNA polymerase II, Rpb4 |
| IPR006590 | Domain | RNA polymerase II, Rpb4, core |
| IPR004589 | Family | DNA helicase, ATP-dependent, RecQ type |
| IPR002121 | Domain | HRDC domain |
| IPR006293 | Family | DNA helicase, ATP-dependent, RecQ type, bacterial |
| IPR022758 | Domain | ATP-dependent helicase Sgs1 |
| IPR010924 | Family | DNA-directed RNA polymerase subunit F (Rpo4) |
| GO Term | Gene Name |
|---|---|
| GO:0000166 | IPR010997 |
| GO:0003824 | IPR010997 |
| GO:0044237 | IPR010997 |
