Protein Domain : IPR011051

Type:  Domain Name:  RmlC-like cupin domain
Description:  RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase; ) is a dTDP-sugar isomerase enzyme involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria []. RmlC is a dimer, each monomer being formed from two beta-sheets arranged in a beta-sandwich, where the substrate-binding site is located between the two sheets of both monomers.Other protein families contain domains that share this fold, including glucose-6-phosphate isomerase (); germin, a metal-binding protein with oxalate oxidase and superoxide dismutases activities []; auxin-binding protein []; seed storage protein 7S []; acireductone dioxygenase []; as well as three proteins that have metal-binding sites similar to that of germine, namely quercetin 2,3-dioxygenase () [], phosphomannose isomerase () [] and homogentisate dioxygenase () [], the last three sharing a 2-domain fold with storage protein 7s. Short Name:  RmlC_Cupin
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8 Child Features

DB identifier Type Name
IPR009327 Domain Cupin domain of unknown function DUF985
IPR013096 Domain Cupin 2, conserved barrel
IPR006045 Domain Cupin 1
IPR024060 Domain Ureidoglycolate lyase domain
IPR008894 Domain WxcM-like, C-terminal
IPR025979 Domain ChrR-like cupin domain
IPR001538 Domain Mannose-6-phosphate isomerase, type II, C-terminal
IPR025974 Domain Mif2/CENP-C cupin domain

3 Contains

DB identifier Type Name
IPR018050 Conserved_site Phosphomannose isomerase, type I, conserved site
IPR019780 Binding_site Germin, manganese binding site
IPR022379 Conserved_site 11-S seed storage protein, conserved site

1 Cross References

Identifier
SSF51182

25 Found Ins

DB identifier Type Name
IPR010424 Family Ethanolamine utilisation EutQ
IPR001250 Family Mannose-6-phosphate isomerase, type I
IPR016305 Family Mannose-6-phosphate isomerase
IPR012093 Family Pirin
IPR004313 Family Acireductone dioxygenase ARD family
IPR005708 Family Homogentisate 1,2-dioxygenase
IPR000526 Family Auxin-binding protein
IPR000888 Family dTDP-4-dehydrorhamnose 3,5-epimerase-related
IPR010300 Family Cysteine dioxygenase type I
IPR012100 Family DNA-damage-repair/toleration protein, DRT102
IPR010329 Family 3-hydroxyanthranilic acid dioxygenase
IPR011983 Family 4-hydroxyphenylacetate catabolism regulatory protein HpaA
IPR016700 Family 3-hydroxyanthranilate 3, 4-dioxygenase, metazoan
IPR016758 Family Glucose-6-phosphate isomerase, archaea/bacteria
IPR016672 Family Polyketide biosynthesis protein CurC, predicted
IPR016847 Family Mannose-6-phosphate isomerase, Firmicutes, long form, predicted
IPR014500 Family Uncharacterised conserved protein UCP019307, cupin-type
IPR017102 Family Uncharacterised conserved protein UCP037087
IPR017627 Family Conserved hypothetical protein CHP03214, putative allantoin-urate catabolism protein
IPR010462 Family Ectoine synthase
IPR017774 Family Bicupin, oxalate decarboxylase/oxidase
IPR014628 Family Mannose-6-phosphate isomerase, Firmicutes type, short form
IPR011960 Family Gentisate 1,2-dioxygenase
IPR012807 Family Anti-sigma factor ChrR, putative
IPR007045 Family 5-keto 4-deoxyuronate isomerase

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR014710 Domain RmlC-like jelly roll fold

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
6160 D8RFN5 PAC:15419402 Selaginella moellendorffii 143  
92705 D8RFF8 PAC:15420608 Selaginella moellendorffii 217  
92738 D8RFG0 PAC:15420673 Selaginella moellendorffii 217  
229747 D8TCF8 PAC:15412958 Selaginella moellendorffii 214  
228015 D8RIQ1 PAC:15404472 Selaginella moellendorffii 212  
411975 D8RJM6 PAC:15412555 Selaginella moellendorffii 190  
172591 D8RLE1 PAC:15412766 Selaginella moellendorffii 421  
69496 D8RLW4 PAC:15417405 Selaginella moellendorffii 102  
412799 D8RMC0 PAC:15414069 Selaginella moellendorffii 741  
78485 D8QUE3 PAC:15421538 Selaginella moellendorffii 217  
78690 D8QW27 PAC:15423094 Selaginella moellendorffii 367  
413209 D8RNP7 PAC:15412851 Selaginella moellendorffii 175  
413206 D8RNP4 PAC:15412847 Selaginella moellendorffii 176  
413204 D8RNP2 PAC:15412843 Selaginella moellendorffii 191  
99342 D8RQH9 PAC:15415830 Selaginella moellendorffii 140  
102742 D8RUY4 PAC:15408350 Selaginella moellendorffii 414  
103237 D8RW68 PAC:15407394 Selaginella moellendorffii 226  
103051 D8RW60 PAC:15405958 Selaginella moellendorffii 214  
415456 D8RW61 PAC:15420332 Selaginella moellendorffii 271  
415460 D8RW67 PAC:15420350 Selaginella moellendorffii 211  
415459 D8RW66 PAC:15420334 Selaginella moellendorffii 358  
270393 D8QX46 PAC:15419662 Selaginella moellendorffii 449  
68172 D8QXS4 PAC:15412147 Selaginella moellendorffii 172  
80801 D8QWH2 PAC:15408243 Selaginella moellendorffii 104  
105500 D8S0C3 PAC:15415629 Selaginella moellendorffii 214  
416854 D8S0L7 PAC:15403869 Selaginella moellendorffii 189  
106525 D8S1H2 PAC:15418553 Selaginella moellendorffii 100  
107333 D8S3A0 PAC:15419952 Selaginella moellendorffii 169  
109785 D8S6T6 PAC:15406615 Selaginella moellendorffii 157  
109767 D8S6J0 PAC:15406562 Selaginella moellendorffii 217  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8612079
            10876237
            10802738
            11062559
            12065401
            11124907
            12402029
            11839311