| Type: | Family | Name: | Pirin |
| Description: | Eukaryotic Pirins are highly conserved nuclear proteins that may function as transcriptional regulators with a role in apoptosis [, ]. Prokaryotic homologues have also been identified. Both bacterial and human Pirins have been shown to possess quercetinase activity [], although this is not universally true for all family members - YhaK (), for example, displays no such enzymatic activity [].Pirin is composed of two structurally similar domains arranged face to face. Although the two domains are similar, the C-terminal domain of Pirin differs from the N-terminal domain as it does not contain a metal binding site and its sequence does not contain the conserved metal-coordinating residues [].Pirin is considered a member of the cupin superfamily on the basis of primary sequence and structural similarity. The presence of a metal binding site in the N-terminal beta-barrel of Pirin, may be significant in its interaction with Bcl-3 and nuclear factor I (NFI) and role in regulating NF-kappaB transcription factor activity []. | Short Name: | Pirin |
