| Type: | Domain | Name: | Mif2/CENP-C cupin domain |
| Description: | This entry represents a C-terminal domain found in Mif2 and CENP-C.CENP-C is the inner-kinetochore centromere (CEN) binding protein. In the budding-yeast, Mif2, the yeast homologue, binds in the CDEIII region of the centromere, and has been shown to recruit a substantial subset of all inner and outer kinetochore proteins []. Mif2 adopts a cupin fold and is extremely similar both in polypeptide chain conformation and in dimer geometry to the dimerisation domain of a bacterial transcription factor []. The Mif2 dimer appears to be part of an enhanceosome-like structure that nucleates kinetochore assembly in budding yeast []. This C-terminal domain is the region via which CENP-C localises to centromeres throughout the cell cycle [, ]. | Short Name: | Mif2/CENP-C_cupin |
