Protein Domain : IPR011050

Type:  Domain Name:  Pectin lyase fold/virulence factor
Description:  Microbial pectin and pectate lyases are virulence factors that degrade the pectic components of the plant cell wall []. When the backbone of pectin is methylated it is known as pectin and is cleaved by pectin lyase, and when it is demethylated it is known as pectate and is cleaved by pectate lyase. Pectin lyase from Aspergillus nigerdisplays a single-stranded, right-handed parallel beta-helix topology (), where each coil contains three beta-strands and three turn regions. Several other virulence factors share this beta-helix topology, although they vary in the number of coils, including bacterial pectate lyases, fungal and bacterial galacturonases (such as rhamnogalacturonase and polygalacturonase), chrondroitinase B from Flavobacterium sp., iota-carrageenase from Alteromonas sp., pectin methylesterase (PemA), P22 tailspike protein from Enterobacteria phage P22, and the virulence factor P.69 pertactin from Bordetella pertussisthat mediates adhesion to target mammalian cells []. Short Name:  Pectin_lyase_fold/virulence
Paste the following link

3 Child Features

DB identifier Type Name
IPR012334 Domain Pectin lyase fold
IPR012332 Domain P22 tailspike C-terminal domain-like
IPR022442 Domain Parallel beta-helix repeat-containing domain

11 Contains

DB identifier Type Name
IPR006626 Repeat Parallel beta-helix repeat
IPR006633 Domain Carbohydrate-binding/sugar hydrolysis domain
IPR008638 Domain Filamentous haemagglutinin, N-terminal
IPR007742 Domain Periplasmic copper-binding protein NosD, beta helix domain
IPR022441 Repeat Parallel beta-helix repeat-2
IPR022444 Repeat Cofactor-binding repeat, putative
IPR013425 Repeat Autotransporter-associated beta strand repeat
IPR011459 Domain Domain of unknown function DUF1565
IPR013687 Domain Disaggregatase-related
IPR004899 Domain Pertactin, central region
IPR018040 Active_site Pectinesterase, active site

1 Cross References

Identifier
SSF51126

5 Found Ins

DB identifier Type Name
IPR022388 Family Conserved hypothetical protein CHP03808
IPR003991 Family Pertactin virulence factor family
IPR003992 Family Pertactin
IPR017318 Family Peptidase S8A, subtilisin-related, campylobacter
IPR000710 Family Peptidase S6, IgA endopeptidase

0 GO Annotation

0 Ontology Annotations

0 Parent Features

40233 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
33909 D8RH98 PAC:15404101 Selaginella moellendorffii 357  
93746 D8RHJ2 PAC:15423531 Selaginella moellendorffii 364  
431083 D8TBF0 PAC:15420038 Selaginella moellendorffii 1062  
431592 D8TD54 PAC:15401533 Selaginella moellendorffii 731  
49812 D8TDA4 PAC:15405825 Selaginella moellendorffii 56  
412910 D8RMQ7 PAC:15415359 Selaginella moellendorffii 338  
78038 D8QWC7 PAC:15418478 Selaginella moellendorffii 455  
78556 D8QUK0 PAC:15422235 Selaginella moellendorffii 439  
54363 D8RPJ3 PAC:15417089 Selaginella moellendorffii 392  
99190 D8RQ82 PAC:15414458 Selaginella moellendorffii 468  
101090 D8RSX7 PAC:15422530 Selaginella moellendorffii 318  
101118 D8RTK9 PAC:15423060 Selaginella moellendorffii 382  
102892 D8RVJ7 PAC:15409316 Selaginella moellendorffii 220  
103305 D8RWJ9 PAC:15408092 Selaginella moellendorffii 285  
232546 D8RWS7 PAC:15420473 Selaginella moellendorffii 286  
405348 D8QX22 PAC:15412371 Selaginella moellendorffii 601  
104861 D8RZ99 PAC:15415118 Selaginella moellendorffii 362  
105243 D8RYY8 PAC:15413444 Selaginella moellendorffii 469  
175869 D8S0H6 PAC:15401391 Selaginella moellendorffii 271  
81583 D8R016 PAC:15409139 Selaginella moellendorffii 308  
81909 D8R0P7 PAC:15412032 Selaginella moellendorffii 350  
111266 D8S8U4 PAC:15408883 Selaginella moellendorffii 410  
13694 D8S9R8 PAC:15410071 Selaginella moellendorffii 232  
419697 D8S9S0 PAC:15411364 Selaginella moellendorffii 194  
419717 D8S9U1 PAC:15411925 Selaginella moellendorffii 505  
113633 D8SD36 PAC:15417766 Selaginella moellendorffii 427  
114014 D8SCR0 PAC:15416093 Selaginella moellendorffii 411  
154356 D8SD12 PAC:15402523 Selaginella moellendorffii 456  
420760 D8SD11 PAC:15415279 Selaginella moellendorffii 533  
83744 D8R0U5 PAC:15416403 Selaginella moellendorffii 333  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9724625
            9195887