Protein Domain : IPR003439

Type:  Domain Name:  ABC transporter-like
Description:  ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found on the same protein or on two different ones. Most ABC transporters function as a dimer and therefore are constituted of four domains, two ABC modules and two TMDs.ABC transporters are involved in the export or import of a wide variety of substrates ranging from small ions to macromolecules. The major function of ABC import systems is to provide essential nutrients to bacteria. They are found only in prokaryotes and their four constitutive domains are usually encoded by independent polypeptides (two ABC proteins and two TMD proteins). Prokaryotic importers require additional extracytoplasmic binding proteins (one or more per systems) for function. In contrast, export systems are involved in the extrusion of noxious substances, the export of extracellular toxins and the targeting of membrane components. They are found in all living organisms and in general the TMD is fused to the ABC module in a variety of combinations. Some eukaryotic exporters encode the four domains on the same polypeptide chain [].The ABC module (approximately two hundred amino acid residues) is known to bind and hydrolyse ATP, thereby coupling transport to ATP hydrolysis in a large number of biological processes. The cassette is duplicated in several subfamilies. Its primary sequence is highly conserved, displaying a typical phosphate-binding loop: Walker A, and a magnesium binding site: Walker B. Besides these two regions, three other conserved motifs are present in the ABC cassette: the switch region which contains a histidine loop, postulated to polarise the attaching water molecule for hydrolysis, the signature conserved motif (LSGGQ) specific to the ABC transporter, and the Q-motif (between Walker A and the signature), which interacts with the gamma phosphate through a water bond. The Walker A, Walker B, Q-loop and switch region form the nucleotide binding site [, , ].The 3D structure of a monomeric ABC module adopts a stubby L-shape with two distinct arms. ArmI (mainly beta-strand) contains Walker A and Walker B. The important residues for ATP hydrolysis and/or binding are located in the P-loop. The ATP-binding pocket is located at the extremity of armI. The perpendicular armII contains mostly the alpha helical subdomain with the signature motif. It only seems to be required for structural integrity of the ABC module. ArmII is in direct contact with the TMD. The hinge between armI and armII contains both the histidine loop and the Q-loop, making contact with the gamma phosphate of the ATP molecule. ATP hydrolysis leads to a conformational change that could facilitate ADP release. In the dimer the two ABC cassettes contact each other through hydrophobic interactions at the antiparallel beta-sheet of armI by a two-fold axis [, , , , , ].The ATP-Binding Cassette (ABC) superfamily forms one of the largest of all protein families with a diversity of physiological functions []. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [, ]. More than 50 subfamilies have been described based on a phylogenetic and functional classification [, , ]; (for further information see http://www.tcdb.org/tcdb/index.php?tc=3.A.1).On the basis of sequence similarities a family of related ATP-binding proteins has been characterised [, , , , ]. The proteins belonging to this family also contain one or two copies of the 'A' consensus sequence [] or the 'P-loop' []. Short Name:  ABC_transporter-like
Paste the following link

3 Child Features

DB identifier Type Name
IPR017902 Domain ABC transporter, beta-glucan-transporting ATPase
IPR015856 Domain ABC transporter, CbiO/EcfA subunit
IPR015860 Domain ABC transporter, teichoic acids export, TagH

6 Contains

DB identifier Type Name
IPR015850 Domain ABC transporter, phosphate import, PstB
IPR015854 Domain ABC transporter, lipoprotein release, LolD
IPR017871 Conserved_site ABC transporter, conserved site
IPR015858 Domain ABC transporter, nickel import, NikE
IPR015857 Domain ABC transporter, nickel import, NikD
IPR015859 Domain ABC transporter, taurine import, TauD

2 Cross Referencess

Identifier
PF00005
PS50893

68 Found Ins

DB identifier Type Name
IPR010230 Family FeS cluster assembly SUF system, ATPase SufC
IPR013283 Family ABC transporter ABCE
IPR005895 Family ABC transporter, haem export, CcmA
IPR011917 Family ABC transporter, lipid A export, MsbA
IPR017917 Family ABC transporter, arabinose import, ATP-binding protein, AraG
IPR012693 Family ABC transporter, phosphonate import, PhnC
IPR005876 Family Cobalt transport protein ATP-binding subunit
IPR010128 Family ATPase, type I secretion system, PrtD
IPR005284 Family Pigment precursor permease
IPR005666 Domain Sulphate transport system permease protein 1
IPR022374 Family ABC transporter, ATP-binding protein, ChvD
IPR015688 Family Elongation Factor 3
IPR017882 Family Zinc import ATP-binding protein ZnuC
IPR005892 Family Glycine betaine transport ATP-binding subunit
IPR015862 Family ABC transporter, galactose import, MglA
IPR015861 Family ABC transporter, ribose import, RbsA
IPR017666 Family 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT2
IPR005894 Family Daunorubicin resistance ABC transporter ATP-binding subunit DrrA
IPR005968 Family Thiamine ABC transporter, ATP-binding protein ThiQ
IPR005670 Family Phosphate transport system permease protein 1
IPR005893 Family Spermidine/putrescine ABC transporter, ATP-binding subunit
IPR017879 Family ABC transporter, spermidine/putrescine import ATP-binding protein, PotA
IPR015863 Family ABC transporter, hemin import, HmuV
IPR005286 Family Cell division protein FtsE, ATP-binding
IPR011924 Family Lipoprotein releasing system, ATP-binding protein
IPR011918 Family ABC transporter, ATP-binding/permease protein
IPR011868 Family Molybdate ABC transporter, ATP-binding protein
IPR017875 Family Aliphatic sulfonates import ATP-binding protein SsuB
IPR017750 Family ATPase, type I secretion system
IPR017911 Domain ABC transporter, macrolide export, ATP-binding domain

2 GO Annotations

GO Term Gene Name
GO:0005524 IPR003439
GO:0016887 IPR003439

2 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR003439
GO:0016887 IPR003439

0 Parent Features

67055 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171117 D8RFW2 PAC:15406523 Selaginella moellendorffii 937  
231453 D8RFW1 PAC:15416787 Selaginella moellendorffii 913  
410515 D8REZ9 PAC:15406347 Selaginella moellendorffii 1222  
92485 D8RF00 PAC:15418498 Selaginella moellendorffii 1239  
93011 D8RFW6 PAC:15418211 Selaginella moellendorffii 835  
93017 D8RG54 PAC:15418217 Selaginella moellendorffii 695  
171469 D8RH21 PAC:15408949 Selaginella moellendorffii 1276  
171321 D8RHS6 PAC:15408019 Selaginella moellendorffii 681  
411220 D8RGY6 PAC:15406937 Selaginella moellendorffii 1065  
93898 D8RGW5 PAC:15402194 Selaginella moellendorffii 611  
93699 D8RHJ5 PAC:15422875 Selaginella moellendorffii 1404  
431004 D8TB78 PAC:15419850 Selaginella moellendorffii 143  
231714 D8RIL0 PAC:15419034 Selaginella moellendorffii 1105  
171782 D8RIJ5 PAC:15411374 Selaginella moellendorffii 644  
147933 D8RKQ9 PAC:15408634 Selaginella moellendorffii 1467  
172462 D8RLS9 PAC:15411936 Selaginella moellendorffii 258  
172580 D8RLA2 PAC:15412742 Selaginella moellendorffii 1424  
412710 D8RL86 PAC:15413851 Selaginella moellendorffii 1781  
412699 D8RL77 PAC:15413246 Selaginella moellendorffii 1446  
441722 D8RL97 PAC:15410157 Selaginella moellendorffii 1700  
441720 D8RL81 PAC:15410156 Selaginella moellendorffii 1687  
441717 D8RL73 PAC:15410131 Selaginella moellendorffii 1379  
61383 D8RLZ0 PAC:15415598 Selaginella moellendorffii 596  
96758 D8RL93 PAC:15410129 Selaginella moellendorffii 1413  
96729 D8RLA4 PAC:15410062 Selaginella moellendorffii 1450  
441803 D8RMN8 PAC:15410892 Selaginella moellendorffii 639  
165716 D8QW54 PAC:15415724 Selaginella moellendorffii 1367  
230134 D8QVC0 PAC:15411565 Selaginella moellendorffii 1329  
438238 D8QV80 PAC:15419600 Selaginella moellendorffii 589  
78362 D8QU09 PAC:15420833 Selaginella moellendorffii 479  

18 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9872322
            9873074
            11421269
            1282354
            9640644
            11402022
            11080142
            11532960
            11421270
            11470432
            11988180
            3288195
            6329717
            2229036
            1977073
            3762694
            3762695
            2126155