| Type: | Family | Name: | Elongation Factor 3 |
| Description: | This entry represents the EF3 (Elongation Factor 3) family. Proteins in this family contain the ABC transporter domains and belong to the family of ABC (ATP-binding cassette) proteins. Yef3 (elongation factor 3A) and Hef3 (elongation factor 3B) are included in this entry. The ribosomal elongation cycle requires two elongation factors: elongation factor 1 alpha (EF-1 alpha), which mediates the binding of an aminoacyl-tRNA to the ribosomal A site, and elongation factor 2 (EF-2), which catalyses the translocation reaction. In yeasts and other higher fungi, a third elongation factor, EF-3 is essential. EF-3 (also known as Yef3 in budding yeast) is required for the binding of the aminoacyl-tRNA-eEF1A-GTP ternary complex to the ribosomal A-site []. EF-3 consists of an N-terminal HEAT repeat domain, followed by a four-helix bundle and two ABC-type ATPase domains, with a chromodomain inserted in ABC2 []. The binding of EF-3 to ribosome may allow tRNA release []. Hef3 is a weakly expressed functional homologue of YEF3. | Short Name: | Elongation_fac_3 |
