Protein Domain : IPR001214

Type:  Domain Name:  SET domain
Description:  The SET domain is a 130 to 140 amino acid, evolutionary well conserved sequence motif that was initially characterised in the Drosophila proteins Su(var)3-9, Enhancer-of-zeste and Trithorax. In addition to these chromosomal proteins modulating gene activities and/or chromatin structure, the SET domain is found in proteins of diverse functions ranging from yeast to mammals, but also including some bacteria and viruses [, ].The SET domains of mammalian SUV39H1 and 2 and fission yeast clr4 have been shown to be necessary for the methylation of lysine-9 in the histone H3 N terminus []. However, this histone methyltransferase (HMTase) activity is probably restricted to a subset of SET domain proteins as it requires the combination of the SET domain with the adjacent cysteine-rich regions, one located N-terminally (pre-SET) and the other posterior to the SET domain (post-SET). Post- and pre- SET regions seem then to play a crucial role when it comes to substrate recognition and enzymatic activity [, ].The structure of the SET domain and the two adjacent regions pre-SET and post-SET have been solved [, , ]. The SET structure is all beta, but consists only in sets of few short strands composing no more than a couple of small sheets. Consequently the SET structure is mostly defined by turns and loops. An unusual feature is that the SET core is made up of two discontinual segments of the primary sequence forming an approximate L shape [, , ]. Two of the most conserved motifs in the SET domain are constituted by (1) a stretch at the C-terminal containing a strictly conserved tyrosine residue and (2) a preceding loop inside which the C-terminal segment passes forming a knot-like structure, but not quite a true knot. These two regions have been proven to be essential for SAM binding and catalysis, particularly the invariant tyrosine where in all likelihood catalysis takes place [, ]. Short Name:  SET_dom
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF00856
PS50280
SM00317

16 Found Ins

DB identifier Type Name
IPR011192 Family Rubisco LSMT methyltransferase, plant
IPR011383 Family N-lysine methyltransferase SETD6
IPR011381 Family Histone H3-K9 methyltransferase
IPR016569 Family Methyltransferase, trithorax
IPR016858 Family Histone H4-K20 methyltransferase
IPR016852 Family SET domain methyltransferase
IPR017111 Family Histone H3-K4 methyltransferase Set1, fungal
IPR009170 Family Predicted retinoblastoma binding protein (RIZ)
IPR009207 Family Histone methyltransferase, PBCV type putative
IPR017124 Family PR-domain zinc finger protein PRDM4
IPR017125 Family PR-domain zinc finger protein PRDM5
IPR017126 Family PR-domain zinc finger protein PRDM12
IPR017155 Family Histone-lysine N-methyltransferase, SET
IPR015722 Family Histone-lysine N-methyltransferase Trr
IPR017119 Family SET domain containing methyltransferase Efm1/Rkm1
IPR011219 Family Rubisco-cytochrome methylase MET

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR001214

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR001214

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231366 D8RF07 PAC:15416091 Selaginella moellendorffii 484  
430576 D8T9U6 PAC:15420901 Selaginella moellendorffii 463  
411158 D8RGR5 PAC:15406301 Selaginella moellendorffii 837  
411740 D8RIW5 PAC:15410962 Selaginella moellendorffii 862  
411741 D8RIW6 PAC:15410963 Selaginella moellendorffii 1167  
412433 D8RLH2 PAC:15411553 Selaginella moellendorffii 721  
412712 D8RL88 PAC:15413853 Selaginella moellendorffii 435  
58821 D8RL94 PAC:15410224 Selaginella moellendorffii 134  
58820 D8RL84 PAC:15410222 Selaginella moellendorffii 134  
404768 D8QWB8 PAC:15412573 Selaginella moellendorffii 664  
78627 PAC:15422919 Selaginella moellendorffii 139  
78536 D8QVC8 PAC:15422184 Selaginella moellendorffii 290  
414102 D8RRN0 PAC:15415037 Selaginella moellendorffii 455  
414101 D8RRM9 PAC:15415036 Selaginella moellendorffii 597  
414219 D8RS19 PAC:15415821 Selaginella moellendorffii 527  
101022 D8RT02 PAC:15422337 Selaginella moellendorffii 508  
102436 D8RV13 PAC:15406056 Selaginella moellendorffii 389  
432361 D8TFS2 PAC:15402805 Selaginella moellendorffii 1531  
79965 D8QYE1 PAC:15405973 Selaginella moellendorffii 491  
80789 D8QXZ1 PAC:15407642 Selaginella moellendorffii 467  
104841 D8RZ91 PAC:15415085 Selaginella moellendorffii 571  
107696 D8S3K9 PAC:15422304 Selaginella moellendorffii 467  
142359 D8QZH7 PAC:15411889 Selaginella moellendorffii 564  
166928 D8R0G6 PAC:15420152 Selaginella moellendorffii 312  
81798 D8R0C9 PAC:15410751 Selaginella moellendorffii 464  
81880 D8QYK5 PAC:15411478 Selaginella moellendorffii 143  
110353 D8S7T5 PAC:15406704 Selaginella moellendorffii 274  
419030 D8S7L0 PAC:15406530 Selaginella moellendorffii 733  
419510 D8S965 PAC:15410416 Selaginella moellendorffii 652  
111860 D8S9D0 PAC:15413560 Selaginella moellendorffii 820  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9632640
            12372294
            10949293
            9487389
            12372305
            12372304
            12372303
            12826405