Protein Domain : IPR009170

Type:  Family Name:  Predicted retinoblastoma binding protein (RIZ)
Description:  Retinoblastoma protein is a tumour suppressor thought to be involved in the transcriptional control of the cell cycle and differentiation. This entry represents RIZ, a zinc-finger protein which has been shown to interact with the retinoblastoma protein, and which is highly expressed in retinoblastoma cell lines and brain tumours [, , ]. Expression has also been demonstrated in a variety of normal cell lines, suggesting a role in cell growth or differentiation. Binding of RIZ to the macrophage-specific TPA-responsive element of the haem oxygenase 1 gene suggests that one its functions is as a transcriptional activator of this gene. Short Name:  RIZ_retinblastoma-bd_prot
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0 Child Features

3 Contains

DB identifier Type Name
IPR001214 Domain SET domain
IPR015880 Domain Zinc finger, C2H2-like
IPR007087 Domain Zinc finger, C2H2

1 Cross References

Identifier
PIRSF002395

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR009170
GO:0046872 IPR009170
GO:0006355 IPR009170
GO:0005634 IPR009170

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR009170
GO:0046872 IPR009170
GO:0006355 IPR009170
GO:0005634 IPR009170

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8654390
            9006946
            7538672