Protein Domain : IPR015880

Type:  Domain Name:  Zinc finger, C2H2-like
Description:  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. C2H2-type (classical) zinc fingers (Znf) were the first class to be characterised. They contain a short beta hairpin and an alpha helix (beta/beta/alpha structure), where a single zinc atom is held in place by Cys(2)His(2) (C2H2) residues in a tetrahedral array. C2H2 Znf's can be divided into three groups based on the number and pattern of fingers: triple-C2H2 (binds single ligand), multiple-adjacent-C2H2 (binds multiple ligands), and separated paired-C2H2 []. C2H2 Znf's are the most common DNA-binding motifs found in eukaryotic transcription factors, and have also been identified in prokaryotes []. Transcription factors usually contain several Znf's (each with a conserved beta/beta/alpha structure) capable of making multiple contacts along the DNA, where the C2H2 Znf motifs recognise DNA sequences by binding to the major groove of DNA via a short alpha-helix in the Znf, the Znf spanning 3-4 bases of the DNA []. C2H2 Znf's can also bind to RNA and protein targets [].This entry represents zinc finger domains resembling the C2H2-type. Short Name:  Znf_C2H2-like
Paste the following link

1 Child Features

DB identifier Type Name
IPR007087 Domain Zinc finger, C2H2

2 Contains

DB identifier Type Name
IPR000690 Domain Zinc finger, C2H2-type matrin
IPR015318 Domain Zinc finger, GAGA-binding factor

1 Cross References

Identifier
SM00355

11 Found Ins

DB identifier Type Name
IPR003604 Domain Zinc finger, U1-type
IPR013087 Domain Zinc finger C2H2-type/integrase DNA-binding domain
IPR007042 Domain Arsenite-resistance protein 2
IPR012866 Family Protein of unknown function DUF1644
IPR012170 Family TFIIH subunit Ssl1/p44
IPR004595 Domain TFIIH C1-like domain
IPR006865 Domain Domain of unknown function DUF629
IPR019485 Domain Zinc finger, V(D)J recombination-activating protein 1
IPR009170 Family Predicted retinoblastoma binding protein (RIZ)
IPR022698 Family Protein of unknown function DUF3505
IPR007071 Family A-kinase anchoring protein 95 (AKAP95)

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410896 PAC:15408808 Selaginella moellendorffii 1196  
93509 D8RHP2 PAC:15421921 Selaginella moellendorffii 145  
411620 D8RII3 PAC:15410103 Selaginella moellendorffii 345  
28310 PAC:15406966 Selaginella moellendorffii 90  
36987 D8RQ19 PAC:15413228 Selaginella moellendorffii 171  
101058 D8RTH9 PAC:15422417 Selaginella moellendorffii 398  
414957 D8RU52 PAC:15421146 Selaginella moellendorffii 157  
405132 D8QYI2 PAC:15410834 Selaginella moellendorffii 181  
80646 D8QY40 PAC:15406828 Selaginella moellendorffii 108  
58353 D8RYU5 PAC:15406381 Selaginella moellendorffii 164  
58350 D8S5N8 PAC:15406379 Selaginella moellendorffii 172  
56696 D8S6I2 PAC:15402894 Selaginella moellendorffii 260  
110681 D8S7B2 PAC:15409085 Selaginella moellendorffii 206  
34350 D8S7T6 PAC:15402580 Selaginella moellendorffii 253  
233860 D8SF68 PAC:15403313 Selaginella moellendorffii 291  
57114 D8SEV6 PAC:15401878 Selaginella moellendorffii 151  
421852 D8SGK0 PAC:15418927 Selaginella moellendorffii 247  
117908 D8SIR0 PAC:15409370 Selaginella moellendorffii 129  
84151 D8R3B7 PAC:15414870 Selaginella moellendorffii 161  
424361 PAC:15401505 Selaginella moellendorffii 1152  
35059 D8R4Z6 PAC:15403196 Selaginella moellendorffii 218  
68340 D8R6C5 PAC:15413651 Selaginella moellendorffii 162  
425147 D8SS58 PAC:15402813 Selaginella moellendorffii 473  
429480 D8T6B6 PAC:15416982 Selaginella moellendorffii 510  
9109 Q5BU22 PAC:15405675 Selaginella moellendorffii 85  
74309 D8QNK5 PAC:15408975 Selaginella moellendorffii 235  
410097 D8RDG5 PAC:15402664 Selaginella moellendorffii 273  
evm.TU.contig_30912.1 PAC:16429903 Carica papaya 200  
evm.TU.contig_31438.1 PAC:16429980 Carica papaya 340  
evm.TU.contig_32926.1 PAC:16430174 Carica papaya 245  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12665246
            15718139
            17210253
            15963892
            10529348
            11179890
            11361095
            10664601
            10940247
            18253864