Protein Domain : IPR017155

Type:  Family Name:  Histone-lysine N-methyltransferase, SET
Description:  This entry represents histone-lysine N-methyltransferase (SETD7 or SET7/9) (), which contains a SET domain []. This enzyme specifically monomethylate Lys-4 of histone H3, thereby creating a specific tag for epigenetic transcriptional activation. Methylation of lysine residues in the N-terminal tails of histones is thought to represent an important component of the mechanism that regulates chromatin structure. As such SETD7 plays a central role in the transcriptional activation of genes such as collagenase and insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 also has methyltransferase activity toward non-histone proteins, including TAF10 and p53/TP53. SETD7 monomethylates Lys-189 of TAF10, which increases the affinity of TAF10 for RNA polymerase II. SETD7 monomethylates Lys-372 of p53/TP53, which stabilises p53/TP53 and increases p53/TP53-mediated transcriptional activation []. These enzymes contain a SET domain, which is necessary but not sufficient for histone methyltransferase activity []. Human SETD7 contains an N-terminal beta-sheet domain in addition to the conserved SET domain []. Mutagenesis studies [] identified two residues in the C terminus of the protein that appear essential for catalytic activity toward lysine-4 of histone H3; cofactor AdoMet binds to this domain. Short Name:  Hist-Lys_N-MeTrfase_SET
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0 Child Features

2 Contains

DB identifier Type Name
IPR001214 Domain SET domain
IPR003409 Repeat MORN motif

2 Cross Referencess

Identifier
PIRSF037249
PS51577

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0018024 IPR017155
GO:0006355 IPR017155
GO:0034968 IPR017155
GO:0005694 IPR017155

4 Ontology Annotations

GO Term Gene Name
GO:0018024 IPR017155
GO:0006355 IPR017155
GO:0034968 IPR017155
GO:0005694 IPR017155

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12372304
            12389038
            12514135
            15525938
            18391193