Protein Domain : IPR027417

Type:  Domain Name:  P-loop containing nucleoside triphosphate hydrolase
Description:  The P-loop NTPase fold is the most prevalent domain of the several distinct nucleotide-binding protein folds.The most common reaction catalysed by enzymes of the P-loop NTPase fold is the hydrolysis of the beta-gamma phosphate bond of a bound nucleoside triphosphate (NTP). The energy from NTP hydrolysis is typically utilised to induce conformational changes in other molecules, which constitutes the basis of the biological functions of most P-loop NTPases. P-loop NTPases show substantial substrate preference for either ATP or GTP []. P-loop NTPases are characterised by two conserved sequence signatures, the Walker A The Walker A motif (the P-loop proper) and Walker B motifs which bind, respectively, the beta and gamma phosphate moieties of the bound NTP, and a Mg2+ cation [].P-loop ATPase domains belong to one of the two major divisions. The kinase-GTPase (KG) division includes the kinases and GTPases, and the ASCE division, characterised by an additional strand in the core sheet, which is located between the P-loop strand and the Walker B strand. Most members of the ASCE division utilise ATP and members of this group include AAA+, ABC, PilT, HerA-FtsK, superfamily 1/2 (SF1/2) helicases, and the RecA/ATP-synthase superfamilies of ATPases, etc [, ]. Short Name:  P-loop_NTPase
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31 Child Features

DB identifier Type Name
IPR031314 Domain Deoxynucleoside kinase domain
IPR008145 Domain Guanylate kinase/L-type calcium channel beta subunit
IPR013317 Domain Chromosomal replication initiator protein DnaA
IPR003593 Domain AAA+ ATPase domain
IPR001208 Domain MCM domain
IPR030378 Domain Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
IPR030381 Domain Dynamin-type guanine nucleotide-binding (G) domain
IPR011579 Domain ATPase domain
IPR005225 Domain Small GTP-binding protein domain
IPR030386 Domain GB1/RHD3-type guanine nucleotide-binding (G) domain
IPR031167 Domain OBG-type guanine nucleotide-binding (G) domain
IPR025723 Domain Anion-transporting ATPase-like domain
IPR030388 Domain Era-type guanine nucleotide-binding (G) domain
IPR030394 Domain HflX-type guanine nucleotide-binding (G) domain
IPR002611 Domain IstB-like ATP-binding protein
IPR002586 Domain CobQ/CobB/MinD/ParA nucleotide binding domain
IPR006703 Domain AIG1-type guanine nucleotide-binding (G) domain
IPR030393 Domain EngB-type guanine nucleotide-binding (G) domain
IPR001609 Domain Myosin head, motor domain
IPR031166 Domain EngA-type guanine nucleotide-binding (G) domain
IPR000863 Domain Sulfotransferase domain
IPR014774 Domain KaiC-like domain
IPR010372 Domain DNA polymerase III delta, N-terminal
IPR004435 Domain Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain
IPR030389 Domain FeoB-type guanine nucleotide-binding (G) domain
IPR025669 Domain AAA domain
IPR030385 Domain IRG-type guanine nucleotide-binding (G) domain
IPR030383 Domain Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain
IPR003714 Domain PhoH-like protein
IPR002543 Domain FtsK domain

0 Contains

2 Cross Referencess

Identifier
G3DSA:3.40.50.300
SSF52540

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

595949 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
448644 PAC:15407428 Selaginella moellendorffii 1386  
430377 D8T981 PAC:15419372 Selaginella moellendorffii 893  
430372 D8T976 PAC:15419370 Selaginella moellendorffii 553  
146742 D8RFQ9 PAC:15404156 Selaginella moellendorffii 428  
10140 D8RF20 PAC:15419664 Selaginella moellendorffii 703  
146823 D8RFZ4 PAC:15404877 Selaginella moellendorffii 428  
171164 D8RG14 PAC:15406646 Selaginella moellendorffii 398  
171117 D8RFW2 PAC:15406523 Selaginella moellendorffii 937  
171046 D8RFP1 PAC:15405828 Selaginella moellendorffii 915  
231444 D8RFU2 PAC:15416761 Selaginella moellendorffii 411  
231460 D8RFX7 PAC:15416814 Selaginella moellendorffii 982  
231453 D8RFW1 PAC:15416787 Selaginella moellendorffii 913  
30474 D8REY9 PAC:15414193 Selaginella moellendorffii 876  
23739 D8RF32 PAC:15417862 Selaginella moellendorffii 229  
410515 D8REZ9 PAC:15406347 Selaginella moellendorffii 1222  
410679 D8RFI0 PAC:15407166 Selaginella moellendorffii 1232  
410613 D8RFA6 PAC:15407024 Selaginella moellendorffii 1812  
410614 D8RFA7 PAC:15407026 Selaginella moellendorffii 609  
410703 D8RFK7 PAC:15407779 Selaginella moellendorffii 548  
410898 D8RG81 PAC:15408810 Selaginella moellendorffii 434  
410880 D8RG59 PAC:15408785 Selaginella moellendorffii 437  
410877 D8RG55 PAC:15408768 Selaginella moellendorffii 736  
410860 D8RG38 PAC:15408740 Selaginella moellendorffii 537  
440890 D8RF70 PAC:15408009 Selaginella moellendorffii 1215  
440930 D8RFG9 PAC:15408704 Selaginella moellendorffii 1033  
440920 D8RFE8 PAC:15408680 Selaginella moellendorffii 1208  
440996 D8RFX1 PAC:15408853 Selaginella moellendorffii 591  
441008 D8RFZ5 PAC:15404621 Selaginella moellendorffii 603  
92201 PAC:15416788 Selaginella moellendorffii 201  
92089 PAC:15415521 Selaginella moellendorffii 210  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11916378
            6329717
            15381417
            14568537