Protein Domain : IPR030389

Type:  Domain Name:  FeoB-type guanine nucleotide-binding (G) domain
Description:  The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling,and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state andan active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.The FeoB family of GTPases is widespread, although not ubiquitous, in Bacteria and Archaea, but missing from Eukaryota. FeoB is involved in the uptake offerrous iron (Fe(2+)), an important cofactor in biological electron transfer and catalysis. Most of the FeoB proteins contain an N-terminal G-domain,connected by an entirely alpha-helical linker peptide to the membrane domain with 8 to 12 predicted membrane-spanning alpha-helices, while in someorganisms the G-domain is expressed separately as a soluble protein. The FeoB- type G domain belongs to the TrmE-Era-EngA-EngB-Septin-like (TEES) superfamilyof the TRAFAC class GTPases.The structure of the FeoB-type G domain follows the typical fold of small GTP- binding proteins, consisting of a seven-stranded beta-sheet surrounded by fivealpha-helices. The ~170-residue FeoB-type G domain harbours five short amino-acid motifs (G1-G5) that are critical in the binding of botha magnesium (Mg(2+)) ion and the guanine nucleotide. The G1 motif (GxxxxGKS/T) (P-loop) is in position to stabilise the beta- and gamma-phosphates of GTP byhydrogen bonds donated by main-chain amides. The threonine of the G2 motif (P/AGxT) coordinates the Mg(2+). The G3 motif (DxxG) interacts with the Mg(2+)and an oxygen of the gamma-phosphate. The G4 motif (NxxD) is involved in recognition of the guanine nucleotide by forming hydrogen bonds to the guaninebase. The G5 motif (S/VSTV]) is, despite low sequence conservation, attributedto critical guanine base coordination [, , , , , ]. Short Name:  G_FEOB_dom
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0 Child Features

0 Contains

1 Cross References

Identifier
PS51711

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0005525 IPR030389

1 Ontology Annotations

GO Term Gene Name
GO:0005525 IPR030389

1 Parent Features

DB identifier Type Name
IPR027417 Domain P-loop containing nucleoside triphosphate hydrolase

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
34064.m000016 B9TFC1 PAC:16826084 Ricinus communis 370  
Zosma07g02130 PAC:50101991 Zostera marina 410  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11916378
            20123128
            19615379
            19629046
            20220129
            20036663