Protein Domain : IPR008145

Type:  Domain Name:  Guanylate kinase/L-type calcium channel beta subunit
Description:  This entry represents a domain found in guanylate kinase () and in L-type calcium channel.Guanylate kinase () (GK) [] catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [, , ] to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel, since they form the drug binding domain. Other properties, such as gating voltage-dependence, G protein modulation and kinase susceptibility, are influenced by alpha-2, delta and beta subunits. Short Name:  GK/Ca_channel_bsu
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0 Child Features

1 Contains

DB identifier Type Name
IPR020590 Conserved_site Guanylate kinase, conserved site

2 Cross Referencess

Identifier
PF00625
SM00072

7 Found Ins

DB identifier Type Name
IPR000584 Family Voltage-dependent calcium channel, L-type, beta subunit
IPR005443 Family Voltage-dependent calcium channel, L-type, beta-1 subunit
IPR005444 Family Voltage-dependent calcium channel, L-type, beta-2 subunit
IPR008079 Family Voltage-dependent calcium channel, L-type, beta-3 subunit
IPR012699 Family Ribose 1,5-bisphosphate phosphokinase PhnN
IPR005419 Family Tight junction protein ZO-2
IPR005420 Family Tight junction protein ZO-3

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR027417 Domain P-loop containing nucleoside triphosphate hydrolase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
85628 D8R6I1 PAC:15421358 Selaginella moellendorffii 306  
85954 D8R6R1 PAC:15401483 Selaginella moellendorffii 217  
evm.model.supercontig_16.46 PAC:16410080 Carica papaya 240  
evm.model.supercontig_92.27 PAC:16428595 Carica papaya 401  
29726.m003918 B9RSS9 PAC:16806631 Ricinus communis 239  
29761.m000433 B9SUG2 PAC:16808119 Ricinus communis 402  
Cucsa.374640.1 A0A0A0KZN8 PAC:16981916 Cucumis sativus 403  
Cucsa.219840.1 A0A0A0K367 PAC:16969867 Cucumis sativus 284  
Cucsa.253910.1 A0A0A0L5P3 PAC:16972165 Cucumis sativus 281  
Cucsa.253900.1 PAC:16972162 Cucumis sativus 295  
Cucsa.253900.2 PAC:16972163 Cucumis sativus 295  
Cucsa.253900.3 PAC:16972164 Cucumis sativus 295  
orange1.1g043263m A0A067G8C3 PAC:18106086 Citrus sinensis 286  
orange1.1g023332m A0A067F9N7 PAC:18091046 Citrus sinensis 284  
orange1.1g015825m A0A067EF80 PAC:18103265 Citrus sinensis 399  
orange1.1g015849m A0A067EF80 PAC:18103264 Citrus sinensis 399  
orange1.1g019061m A0A067EIM3 PAC:18103266 Citrus sinensis 346  
AT3G06200.1 Q94JM2 PAC:19659614 Arabidopsis thaliana 282  
AT3G57550.2 F4J3E9 PAC:19663724 Arabidopsis thaliana 390  
AT3G57550.1 Q9M682 PAC:19663725 Arabidopsis thaliana 389  
AT2G41880.1 P93757 PAC:19641833 Arabidopsis thaliana 387  
Thhalv10016777m V4MCJ8 PAC:20181304 Eutrema salsugineum 388  
Thhalv10021285m V4LG02 PAC:20182446 Eutrema salsugineum 280  
Thhalv10006029m V4LWP6 PAC:20190705 Eutrema salsugineum 389  
Thhalv10016095m V4N877 PAC:20206660 Eutrema salsugineum 287  
Ciclev10026219m V4UP55 PAC:20799917 Citrus clementina 284  
Ciclev10005567m V4S7Y9 PAC:20790707 Citrus clementina 286  
Ciclev10005107m V4S307 PAC:20792516 Citrus clementina 399  
Ciclev10005109m V4S307 PAC:20792515 Citrus clementina 399  
Lus10021947 PAC:23158015 Linum usitatissimum 291  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1310897
            8097461
            1314905
            1329277