Protein Domain : IPR017848

Type:  Family Name:  RNA polymerase sigma factor, RpoD-like, cyanobacteria
Description:  The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. RNA polymerase recruits alternative sigma factors as a means of switching on specific regulons. Most bacteria express a multiplicity of sigma factors. Two of these factors, sigma-70 (gene rpoD), generally known as the major or primary sigma factor, and sigma-54 (gene rpoN or ntrA) direct the transcription of a wide variety of genes. The other sigma factors, known as alternative sigma factors, are required for the transcription of specific subsets of genes.With regard to sequence similarity, sigma factors can be grouped into two classes, the sigma-54 and sigma-70 families. Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase; and sub-region 4.2, which seems to harbor a DNA-binding 'helix-turn-helix' motif involved in binding the conserved -35 region of promoters recognised by the major sigma factors [, ]. This family includes a number of closely related sigma-70 () factors in the cyanobacteria. All appear most closely related to the essential sigma-70 factor RpoD, and some are related to the RpoD C-terminal domain model (). Short Name:  RNA_pol_sigma_RpoD_cyanobac
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0 Child Features

8 Contains

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR013324 Domain RNA polymerase sigma factor, region 3/4
IPR013325 Domain RNA polymerase sigma factor, region 2
IPR007627 Domain RNA polymerase sigma-70 region 2
IPR007630 Domain RNA polymerase sigma-70 region 4
IPR000943 Domain RNA polymerase sigma-70
IPR007624 Domain RNA polymerase sigma-70 region 3
IPR009042 Domain RNA polymerase sigma-70 region 1.2

1 Cross References

Identifier
TIGR02997

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

10 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Sphfalx0150s0034.1.p PAC:32606403 Sphagnum fallax 624  
Pp3c14_22330V3.1.p PAC:32960020 Physcomitrium patens 579  
Pp3c14_22334V3.1.p PAC:32962730 Physcomitrium patens 579  
Mapoly0214s0004.1.p K0ISZ8 PAC:33016404 Marchantia polymorpha 615  
Sphmag12G062700.1.p PAC:41931775 Sphagnum magellanicum 624  
Sphfalx12G058000.4.p PAC:41954673 Sphagnum fallax 620  
Sphfalx12G058000.1.p PAC:41954672 Sphagnum fallax 624  
CepurR40.2G161400.1.p PAC:42995518 Ceratodon purpureus R40 604  
CepurR40.6G038900.1.p PAC:43011732 Ceratodon purpureus R40 580  
CepurGG1.6G035700.1.p PAC:43057364 Ceratodon purpureus GG1 580  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            1597408
            3092189