Protein Domain : IPR007624

Type:  Domain Name:  RNA polymerase sigma-70 region 3
Description:  The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. RNA polymerase recruits alternative sigma factors as a means of switching on specific regulons. Most bacteria express a multiplicity of sigma factors. Two of these factors, sigma-70 (gene rpoD), generally known as the major or primary sigma factor, and sigma-54 (gene rpoN or ntrA) direct the transcription of a wide variety of genes. The other sigma factors, known as alternative sigma factors, are required for the transcription of specific subsets of genes.With regard to sequence similarity, sigma factors can be grouped into two classes, the sigma-54 and sigma-70 families. Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase; and sub-region 4.2, which seems to harbor a DNA-binding 'helix-turn-helix' motif involved in binding the conserved -35 region of promoters recognised by the major sigma factors [, ]. Region 3 forms a discrete compact three helical domain within the sigma-factor. Region is not normally involved in the recognition of promoter DNA, but in some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role. Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme []. Short Name:  RNA_pol_sigma70_r3
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0 Child Features

0 Contains

1 Cross References

Identifier
PF04539

13 Found Ins

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR014284 Domain RNA polymerase sigma-70 like domain
IPR013324 Domain RNA polymerase sigma factor, region 3/4
IPR000943 Domain RNA polymerase sigma-70
IPR016262 Family RNA polymerase sigma factor, SigB/C/D/F, plastid
IPR012760 Domain RNA polymerase sigma factor RpoD, C-terminal
IPR017848 Family RNA polymerase sigma factor, RpoD-like, cyanobacteria
IPR012761 Family RNA polymerase sigma factor RpoS
IPR012845 Family RNA polymerase sigma factor, FliA/WhiG
IPR014322 Family RNA polymerase sigma-B/F/G type
IPR014236 Family RNA polymerase sigma-F type
IPR014288 Family RNA polymerase sigma-B factor
IPR014212 Family RNA polymerase sigma-G type

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR007624
GO:0003700 IPR007624
GO:0016987 IPR007624
GO:0006352 IPR007624
GO:0006355 IPR007624

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR007624
GO:0003700 IPR007624
GO:0016987 IPR007624
GO:0006352 IPR007624
GO:0006355 IPR007624

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
147096 D8RGX1 PAC:15401952 Selaginella moellendorffii 458  
53596 D8S3G8 PAC:15415781 Selaginella moellendorffii 326  
117159 D8SHL6 PAC:15403291 Selaginella moellendorffii 292  
evm.model.supercontig_125.39 PAC:16407269 Carica papaya 443  
evm.model.supercontig_3.54 PAC:16416838 Carica papaya 547  
evm.model.supercontig_3807.1 PAC:16418945 Carica papaya 333  
evm.model.supercontig_56.16 PAC:16422721 Carica papaya 564  
29794.m003368 B9RRX0 PAC:16808728 Ricinus communis 560  
29864.m001444 B9RVK0 PAC:16811756 Ricinus communis 389  
30078.m002307 B9S0J0 PAC:16817418 Ricinus communis 548  
30148.m001412 B9SDA3 PAC:16820557 Ricinus communis 569  
30148.m001468 B9SDF8 PAC:16820612 Ricinus communis 508  
30169.m006532 B9RIL8 PAC:16821332 Ricinus communis 501  
Cucsa.362600.1 A0A0A0K917 PAC:16980950 Cucumis sativus 580  
Cucsa.012950.1 PAC:16951584 Cucumis sativus 585  
Cucsa.012950.2 A0A0A0LCQ9 PAC:16951585 Cucumis sativus 547  
Cucsa.124610.1 A0A0A0KEQ6 PAC:16961743 Cucumis sativus 562  
Cucsa.073340.2 PAC:16955602 Cucumis sativus 473  
Cucsa.073340.1 A0A0A0LQR2 PAC:16955601 Cucumis sativus 508  
Cucsa.160980.1 PAC:16965441 Cucumis sativus 473  
Cucsa.248920.1 A0A0A0L9T0 PAC:16971515 Cucumis sativus 436  
orange1.1g010308m A0A067EY28 PAC:18126912 Citrus sinensis 513  
orange1.1g010092m A0A067ELT2 PAC:18126911 Citrus sinensis 518  
orange1.1g010284m A0A067EY28 PAC:18126913 Citrus sinensis 513  
orange1.1g010327m A0A067EY28 PAC:18126914 Citrus sinensis 513  
orange1.1g010338m A0A067EY28 PAC:18126915 Citrus sinensis 513  
orange1.1g013447m A0A067E2F5 PAC:18139602 Citrus sinensis 443  
orange1.1g014764m A0A067EAT8 PAC:18139603 Citrus sinensis 419  
orange1.1g014852m A0A067E9X3 PAC:18139604 Citrus sinensis 417  
orange1.1g010521m A0A067E9X0 PAC:18139598 Citrus sinensis 508  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            1597408
            3092189
            11931761