Protein Domain : IPR014322

Type:  Family Name:  RNA polymerase sigma-B/F/G type
Description:  The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. RNA polymerase recruits alternative sigma factors as a means of switching on specific regulons. Most bacteria express a multiplicity of sigma factors. Two of these factors, sigma-70 (gene rpoD), generally known as the major or primary sigma factor, and sigma-54 (gene rpoN or ntrA) direct the transcription of a wide variety of genes. The other sigma factors, known as alternative sigma factors, are required for the transcription of specific subsets of genes.With regard to sequence similarity, sigma factors can be grouped into two classes, the sigma-54 and sigma-70 families. Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase; and sub-region 4.2, which seems to harbor a DNA-binding 'helix-turn-helix' motif involved in binding the conserved -35 region of promoters recognised by the major sigma factors [, ]. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:and SigG:as well as SigB:), and the high GC Gram-positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage. Short Name:  RNA_pol_sigma-B/F/G
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3 Child Features

DB identifier Type Name
IPR014236 Family RNA polymerase sigma-F type
IPR014288 Family RNA polymerase sigma-B factor
IPR014212 Family RNA polymerase sigma-G type

7 Contains

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR013324 Domain RNA polymerase sigma factor, region 3/4
IPR013325 Domain RNA polymerase sigma factor, region 2
IPR007627 Domain RNA polymerase sigma-70 region 2
IPR007630 Domain RNA polymerase sigma-70 region 4
IPR000943 Domain RNA polymerase sigma-70
IPR007624 Domain RNA polymerase sigma-70 region 3

1 Cross References

Identifier
TIGR02980

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR014322
GO:0003700 IPR014322
GO:0016987 IPR014322
GO:0006352 IPR014322
GO:0006355 IPR014322

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR014322
GO:0003700 IPR014322
GO:0016987 IPR014322
GO:0006352 IPR014322
GO:0006355 IPR014322

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            1597408
            3092189