GO Term : GO:0097194 execution phase of apoptosis GO

Namespace:  biological_process Obsolete:  false
description  A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

15 Parents

Identifier Name Description
GO:0008219 cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
GO:0006915 apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GO:0016043 cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0071840 cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0022607 cellular component assembly The aggregation, arrangement and bonding together of a cellular component.
GO:0030030 cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
GO:0016265 death A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
GO:0012501 programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GO:0030031 cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
GO:0097194 execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GO:0032060 bleb assembly The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.

53 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0097194 GO:0006309
part of GO:0097194 GO:0006921
part of GO:0097194 GO:0006921
part of GO:0097194 GO:0030262
part of GO:0097194 GO:0030263
part of GO:0097194 GO:0030264
part of GO:0097194 GO:0070782
is_a GO:0044763 GO:0097194
has_part GO:0032060 GO:0097194
part of GO:0006915 GO:0097194
has_part GO:0008150 GO:0097194
is_a GO:0044699 GO:0097194
is_a GO:0008150 GO:0097194
has_part GO:0044699 GO:0097194
has_part GO:0044763 GO:0097194
part of GO:0012501 GO:0097194
part of GO:0008150 GO:0097194
is_a GO:0009987 GO:0097194
part of GO:0044699 GO:0097194
part of GO:0044763 GO:0097194
part of GO:0016265 GO:0097194
has_part GO:0016043 GO:0097194
has_part GO:0009987 GO:0097194
has_part GO:0071840 GO:0097194
has_part GO:0030030 GO:0097194
has_part GO:0030031 GO:0097194
part of GO:0009987 GO:0097194
part of GO:0008219 GO:0097194
has_part GO:0022607 GO:0097194
part of GO:0097194 GO:0097200

2 Synonyms

Name Type
apoptosis synonym
execution phase of apoptotic process synonym