| Type: | Family | Name: | Impact family, bacterial/archaeal |
| Description: | The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea []. This entry represents Impact family members found mostly in bacteria, though there are also some archaeal sequences as well. Crystallography of the Escherichia coli protein YigZ shows a two-domain stucture, where the C-terminal domain is suggested to bind nucleic acids. The function of this proteins is unknown []. | Short Name: | Impact_bac/arc |
| DB identifier | Type | Name |
|---|---|---|
| IPR020568 | Domain | Ribosomal protein S5 domain 2-type fold |
| IPR009022 | Domain | Elongation factor G, III-V domain |
| IPR001498 | Domain | Impact, N-terminal |
| IPR015269 | Domain | Uncharacterised domain UPF0029, Impact, C-terminal |
| IPR020569 | Conserved_site | Uncharacterised protein family UPF0029, Impact, conserved site |
