Protein Domain : IPR009220

Type:  Family Name:  Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
Description:  This entry describes a probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein. Its N-termanal domain is homologous to the Kae1/YgjD family, which is involved in tRNA threonylcarbamoyladenosine biosynthesis []. Its C-terminal region contains a serine/threonine protein kinase domain (STYKS) and is homologous to Bud32. Kae1 and Bud32 are two components of the the KEOPS/EKC complex, which has been implicated in transcription, telomere maintenance and chromosome segregation []. In this archaeal family, it seems that the Kae1 and Bud32 orthologues are fused. Short Name:  tRNA_threonyl_synthase/kinase
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0 Child Features

5 Contains

DB identifier Type Name
IPR000905 Domain Gcp-like domain
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR017860 Conserved_site Peptidase M22, conserved site

2 Cross Referencess

Identifier
PIRSF036401
MF_01447

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004222 IPR009220
GO:0008270 IPR009220

2 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR009220
GO:0008270 IPR009220

1 Parent Features

DB identifier Type Name
IPR022449 Family tRNA N6-adenosine threonylcarbamoyltransferase, Kae1

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21183954
            21285948