Protein Domain : IPR000385

Type:  Conserved_site Name:  MoaA/nifB/pqqE, iron-sulphur binding, conserved site
Description:  A number of proteins involved in the biosynthesis of metallo cofactors have been shown [, ] to be evolutionary related. These include:Bacterial and archebacterial protein moaA, which is involved in the biosynthesis of the molybdenum cofactor (molybdopterin; MPT).Arabidopsis thaliana(Mouse-ear cress) cnx2, a protein involved in molybdopterin biosynthesis and which is highly similar to moaA.Bacillus subtilisnarA, which seems to be the moaA ortholog in that bacteria.Bacterial protein nifB (or fixZ) which is involved in the biosynthesis of the nitrogenase iron-molybdenum cofactor.Bacterial protein pqqE which is involved in the biosynthesis of the cofactor pyrrolo-quinoline-quinone (PQQ).Pyrococcus furiosuscmo, a protein involved in the synthesis of a molybdopterin-based tungsten cofactor.Caenorhabditis eleganshypothetical protein F49E2.1.These proteins share, in their N-terminal region, a conserved domain that contains three cysteines. In moaA, these cysteines have been shown to be important for biological activity by binding a [4Fe-4S]cluster []. The three cysteines each coordinate one Fe, while S-adenosylmethionine is the fourth ligand to the cluster and binds to its unique Fe as an N/O chelate. Short Name:  MoaA_NifB_PqqE_Fe-S-bd_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS01305

7 Found Ins

DB identifier Type Name
IPR013785 Domain Aldolase-type TIM barrel
IPR007197 Domain Radical SAM
IPR006638 Domain Elongator protein 3/MiaB/NifB
IPR013483 Family Molybdenum cofactor biosynthesis protein A
IPR011843 Family Coenzyme PQQ biosynthesis protein E, bacteria
IPR013485 Family Molybdenum cofactor biosynthesis protein A, archaea
IPR005980 Family Nitrogenase cofactor biosynthesis protein NifB

3 GO Annotations

GO Term Gene Name
GO:0003824 IPR000385
GO:0046872 IPR000385
GO:0051539 IPR000385

3 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR000385
GO:0046872 IPR000385
GO:0051539 IPR000385

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8588735
            7890743
            15317939